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Avasopasem manganese
Brand：MedChemExpress (MCE)
Cat. No：HY-109110
CAS：435327-40-5
Synonyms：GC-4419; M-40419
Purity：0.9602
Storage：
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Avasopasem manganese (GC4419; M-40419) is a potent superoxide dismutase mimetic that rapidly and specifically converts O2*- to hydrogen peroxide (H2O2), arresting the initiation of this cascade. Avasopasem manganese can be used for the research of severe oral mucositis (SOM) and cancer[1].
In Vivo：
Avasopasem manganese is an agent intended to interrupt severe oral mucositis pathogenesis, to reduce the duration, incidence, and severity of radiation-induced oral mucositis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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References：
[1]. Anderson CM, et al. Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer [published correction appears in J Clin Oncol. 2020 Jan 20;38(3):288]. J Clin Oncol. 2019;37(34):3256-3265.
Brand Introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing global scientific research customers with the most comprehensive range of high-quality small molecule active compounds;
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• The biological activity of the products has been experimentally verified by customers from various countries;
A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers;
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