分子量:67.2 kDa

纯度:>90% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human Cadherin-6, His Tag by the LAL method.

Buffer:PBS, pH7.4

生物活性:

产品特性:Human Cadherin-6, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 67.2 kDa. The predicted N-terminus is Thr 19. The reducing (R) protein migrates as 90-100 kDa in SDS-PAGE  due to glycosylation.

产品背景:Cadherin-6 (CDH6) is also known as Kidney cadherin (K-cadherin or KCAD), is a  a type II classical cadherin from the cadherin superfamily. Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH6 / KCAD contains five cadherin domains. CDH6 is highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression and also expressed in certain liver and kidney carcinomas.