Phospho-JunB (Thr102 + Thr104),磷酸化活化蛋白激酶B抗体

产品编号HZ-11228R
英文名称Phospho-JunB (Thr102 + Thr104)
中文名称磷酸化活化蛋白激酶B抗体
别 名Phospho-JunB (Thr102/Thr104); P-JunB (Phospho Thr102/Thr104); Activator protein 1; AP 1; AP1; Jun B; Jun B proto oncogene; Jun B protooncogene; JunB proto oncogene; JunB protoncogene 9; JunB protooncogene; Transcription factor jun B; Transcription factor junB; JUNB_HUMAN; Transcription factor jun-B; Transcription factor junB.
说 明 书0.1ml
产品类型磷酸化抗体
研究领域肿瘤 转录调节因子 激酶和磷酸酶
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Guinea Pig,
Phospho-JunB (Thr102 + Thr104),磷酸化活化蛋白激酶B抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量38kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human JunB around the phosphorylation site of Thr102/Thr104 [TT(p-T)P(p-T)PP]
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Phospho-JunB (Thr102 + Thr104),磷酸化活化蛋白激酶B抗体PubMedPubMed
产品介绍background:
The cJun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus vjun oncogene. JunB and JunD have been shown to be almost identical to cJun in their C terminal regions, which are involved in dimerization and DNA binding, whereas their N terminal domains, which are involved in transcriptional activation, diverge. JunB is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'.

Function:
Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.

Subunit:
Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Interacts with ITCH (via its WW domains).

Subcellular Location:
Nucleus.

Post-translational modifications:
Ubiquitinated by ITCH, leading to its degradation.

Phospho-JunB (Thr102 + Thr104),磷酸化活化蛋白激酶B抗体Similarity:
Belongs to the bZIP family. Jun subfamily.
Contains 1 bZIP (basic-leucine zipper) domain.

Database links:
Entrez Gene: 3726 Human
Entrez Gene: 16477 Mouse
Entrez Gene: 24517 Rat
Omim: 165161 Human
SwissProt: P17275 Human
SwissProt: P09450 Mouse
SwissProt: P24898 Rat
Unigene: 25292 Human
Unigene: 1167 Mouse
Unigene: 470093 Mouse
Unigene: 15806 Rat

Phospho-JunB (Thr102 + Thr104),磷酸化活化蛋白激酶B抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.