MARCH6,膜相关环指蛋白6抗体

产品编号HZ-9340R
英文名称MARCH6
中文名称膜相关环指蛋白6抗体
别 名Doa10 homolog; E3 ubiquitin protein ligase MARCH6; MARCH 6; MARCH VI; MARCHVI; Membrane associated RING CH protein VI; Membrane associated ring finger (C3HC4) 6; Membrane associated RING finger protein 6; Protein TEB 4; Protein TEB4; RNF 176; RNF176; TEB 4; TEB4; RING finger protein 176; MARH6_HUMAN.
规格价格0.1ml/980元 购买 0.2ml/1580元 购买
说 明 书0.1ml 0.2ml
研究领域细胞生物 细胞周期蛋白 通道蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Zebrafish, Sheep,
MARCH6,膜相关环指蛋白6抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量103kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human MARCH6
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
MARCH6,膜相关环指蛋白6抗体PubMedPubMed
产品介绍background:
MARCH6 (Membrane associated RING finger protein 6) belongs to the MARCH family, which contains at least seven membrane associated RING-CH (MARCH)proteins. MARCH proteins are E3 ubiquitin ligases and are located to subcellular membranes.

Function:
E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1.

Subunit:
Interacts with DIO2.

Subcellular Location:
Endoplasmic reticulum membrane; Multi pass membrane protein.

Tissue Specificity:
Present in brain (at protein level).

Post-translational modifications:
Auto-ubiquitinated, which results in proteasomal degradation.

MARCH6,膜相关环指蛋白6抗体Similarity:
Contains 1 RING-CH-type zinc finger.

Gene ID:
10299

Database links:
Entrez Gene: 10299 Human
Entrez Gene: 223455 Mouse
Entrez Gene: 294862 Rat
Omim: 613297 Human
SwissProt: O60337 Human
SwissProt: Q6ZQ89 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.