Endonuclease V,核酸内切酶V抗体

产品编号HZ-14593R
英文名称Endonuclease V
中文名称核酸内切酶V抗体
别 名A730011L01Rik; Endonuclease V; ENDOV; ENDOV_MOUSE.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Mouse, Rat,
Endonuclease V,核酸内切酶V抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量37kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from mouse Endonuclease V
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Endonuclease V,核酸内切酶V抗体PubMedPubMed
产品介绍background:
Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.

Function:
Selectively cleaves DNA at the second phosphodiester bond 3' to hypoxanthine- and uracil-containing nucleotides. Shows higher activity towards single-stranded than double-stranded DNA and towards hypoxanthine than uracil.

Endonuclease V,核酸内切酶V抗体Tissue Specificity:
Highest levels detected in liver with high levels also found in heart, kidney and testis. Expressed at low levels in brain.

Post-translational modifications:

Similarity:
Belongs to the endonuclease V family.

Gene ID:
338371

Database links:
Entrez Gene: 338371 Mouse
SwissProt: Q8C9A2 Mouse
Unigene: 728933 Human
Unigene: 271946 Mouse

Endonuclease V,核酸内切酶V抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.