ETS1,转录因子家族ETS1抗体

产品编号HZ-1285R
英文名称ETS1
中文名称转录因子家族ETS1抗体
别 名Avian erythroblastosis virus E26 (v ets) oncogene homolog 1; C ets 1 protein; ETS 1; Ets protein; ETS-1; ETS1 protein; ETS1_HUMAN; EWSR 2; EWSR2; FLJ10768; p54; Protein C-ets-1; v ets avian erythroblastosis virus E2 oncogene homolog; v ets avian erythroblastosis virus E26 oncogene homolog 1; v ets erythroblastosis virus E26 oncogene homolog 1; v-ets erythroblastosis virus E26 oncogene homolog 1.
说 明 书0.1ml 0.2ml
研究领域肿瘤 免疫学 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, G
ETS1,转录因子家族ETS1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量49kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Ets1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
ETS1,转录因子家族ETS1抗体PubMedPubMed
产品介绍background:
This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011].

Function:
Transcription factor.

Subunit:
Interacts with MAF and MAFB. Interacts with PAX5, the interaction alters DNA-binding properties. Binds to DAXX. Interacts with UBE2I.

Subcellular Location:
Nucleus.

Post-translational modifications:
Sumoylated on Lys-15 and Lys-227, preferentially by SUMO2; which inhibits transcriptional activity.
Ubiquitinated; which induces proteasomal degradation.

ETS1,转录因子家族ETS1抗体Similarity:
Belongs to the ETS family.
Contains 1 ETS DNA-binding domain.
Contains 1 PNT (pointed) domain.

Gene ID:
2113

Database links:
Entrez Gene: 540313 Cow
Entrez Gene: 2113 Human
Entrez Gene: 23871 Mouse
Entrez Gene: 24356 Rat
Omim: 164720 Human
SwissProt: P13474 Chicken
SwissProt: P15062 Chicken
SwissProt: P14921 Human
SwissProt: P27577 Mouse
SwissProt: P41156 Rat
Unigene: 369438 Human
Unigene: 292415 Mouse
Unigene: 88756 Rat

ETS1,转录因子家族ETS1抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Ets家族成员在胚胎发生早期的血细胞生成和血管发生及胚胎发育后期的组织发生中发挥重要的调控作用. 成年后Ets在许多组织，如造血组织、血管、脑和中枢神经系统、乳腺、子宫内膜、卵巢、睾丸、肾和肺中均有表达. 由于Ets转录因子不同成员在胚胎发育过程中的特异性的表达与其功能关系密切。
Ets家族的重要成员Ets-1的表达与胰腺癌、甲状腺癌、乳腺癌、胃癌、子宫内膜癌、口腔鳞癌、肝细胞性肝癌(HCC)的发生、转移有很重要的关系。