Adenosine A3 Receptor,腺苷受体A3抗体

产品编号HZ-1225R
英文名称Adenosine A3 Receptor
中文名称腺苷受体A3抗体
别 名adenosine A3 receptor; A3AR; AD 026; AD026; ADORA 3; ADORA3; bA552M11.5; RP11 552M11.7; TGPCR1; adenosine receptor A3 isoform 1; adenosine receptor A3 isoform 2; AA3R_HUMAN.
规格价格0.1ml/ 0.2ml/
说 明 书0.1ml 0.2ml
研究领域心血管 神经生物学 细胞膜受体 G蛋白偶联受体
抗体来源Rabbit
克隆类型Polyclonal
Adenosine A3 Receptor,腺苷受体A3抗体交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量35kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ADORA3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Adenosine A3 Receptor,腺苷受体A3抗体PubMedPubMed
产品介绍background:
This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Function:
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction.

Subcellular Location:
Cell membrane.

Post-translational modifications:
Phosphorylation on Ser-317 may be crucial for rapid desensitization.

Adenosine A3 Receptor,腺苷受体A3抗体Similarity:
Belongs to the G-protein coupled receptor 1 family.

Gene ID:
140

Database links:
Entrez Gene: 403805 Dog
Entrez Gene: 140 Human
Entrez Gene: 606753 Pig
Omim: 600445 Human
SwissProt: Q28309 Dog
SwissProt: P33765 Human
SwissProt: Q6P2N6 Human
Unigene: 281342 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

ADORA-3(腺苷受体A3)属于G蛋白偶联受体家族，在腺苷调节细胞活力和生长中起关键作用，并且在很多肿瘤中表达增高，A3AR可能成为肿瘤诊断标志物和治疗靶点。

产品图片

Tissue/cell: human gastric carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;  Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;  Incubation: Anti-ADORA3 Polyclonal Antibody, Unconjugated(bs-1225R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining