FITC标记的原癌基因FRAT1抗体
产品名称： FITC标记的原癌基因FRAT1抗体
英文名称： Anti-FRAT1/FITC
产品编号： HZ-12434R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-FRAT1/FITC Conjugated antibody
FITC标记的原癌基因FRAT1抗体
| 英文名称 | Anti-FRAT1/FITC |
| 中文名称 | FITC标记的原癌基因FRAT1抗体 |
| 别 名 | FRAT 1; frequently rearranged in advanced T cell lymphomas; Frequently rearranged in advanced T-cell lymphomas; GSK 3 binding protein FRAT1; proto oncogene FRAT1; FRAT1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 发育生物学 信号转导 干细胞 淋巴细胞 t-淋巴细胞 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 29kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FRAT1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈. |
| 产品介绍 | background: FRAT1 and FRAT2 were originally characterized as proteins frequently rearranged in advanced T cell lymphoma, and they have since been identified as proto-oncogenes involved in tumorigenesis. These proteins share significant homology with the Xenopus glycogen synthase kinase-3 (xGSK-3) binding protein, which is designated GBP and is essential for the formation of the dorsal-ventral axis during embryonic development. Establishment of these embryonic axes is mediated by the Wnt intracellular signaling pathway. Wnt signaling is regulated in part by the activity of GSK-3, which phosphorylates and thereby facilitates the degradation of ?catenin. GBP binds to GSK-3 and inhibits this phosphorylation, resulting in the accumulation of ?catenin and the subsequent transcription of Wnt target genes. Like GBP, FRAT2 has been shown to bind xGSK-3, suggesting that FRAT1 and FRAT2 may be GSK-3 regulatory proteins. Function: The protein encoded by the FRAT1 gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and also positively regulates the Wnt signaling pathway. It may play a role in tumor progression and in lymphomagenesis. Subunit: Binds DVL1. Binds GSK-3 and prevent GSK-3-dependent phosphorylation. Subcellular Location: Cytoplasmic. Post-translational modifications: Phosphorylated (By similarity). Similarity: Belongs to the GSK-3-binding protein family. Database links: UniProtKB/Swiss-Prot: Q92837.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
FRAT1和FRAT2原本是晚期T细胞淋巴瘤中频繁重排的蛋白质，后来被鉴定为参与肿瘤发生的原癌基因。这些蛋白与爪蟾糖原合成酶激酶-3(xGSK-3)结合蛋白具有显著的同源性，该结合蛋白被命名为GBP，在胚胎发育过程中对背腹轴的形成是必不可少的。这些胚胎轴的建立是由Wnt信号转导通路介导的。Wnt信号传导部分受GSK-3活性的调控，GSK-3的活性是磷酸化的，从而有利于降解？连环蛋白GBP结合GSK-3并抑制这种磷酸化，导致积累？连环蛋白和Wnt靶基因的随后转录。与GBP一样，FRAT2已被证明结合XGSK-3，提示FRAT1和FRAT2可能是GSK-3调节蛋白。