FITC标记的淋巴管内皮透明质酸受体抗体
产品名称： FITC标记的淋巴管内皮透明质酸受体抗体
英文名称： Anti-LYVE-1/FITC
产品编号： HZ-20120R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-LYVE-1/FITC Conjugated antibody
FITC标记的淋巴管内皮透明质酸受体抗体
| 英文名称 | Anti-LYVE-1/FITC |
| 中文名称 | FITC标记的淋巴管内皮透明质酸受体抗体 |
| 别 名 | LYVE1; lymphalic vessel endotheilial hyaluronan receptor 1; CRSBP 1; CRSBP1; extracellular link domain containing 1; extracellular link domain-containing 1; HAR; hyaluronic acid receptor; Cell surface retention sequence-binding protein 1; CRSBP-1; extracellular link domain-containing 1; Extracellular link domain-containing protein 1; Lymphatic vessel endothelial hyaluronic acid receptor 1; LYVE1_HUMAN; Lymphatic endothelium specific hyaluronan receptor; LYVE 1; LYVE-1; XLKD1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 32kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LYVE-1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The lymphatic vasculature forms a second circulatory system that drains extracellular fluid from the tissues and provides an exclusive environment in which immune cells can encounter and respond to foreign antigen. Recently a number of interesting molecules have been identified that may be exploited as markers for lymphatic endothelium, including the hyaluronan receptor LYVE1, PALE, VEGFR3, podoplanin. LYVE1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves. Function: Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. Subunit: Homodimer; disulfide-linked. Interacts with PDGFB and IGFBP3. Forms a transient ternary complex with PDGFB and PDGFRB in TGN. Subcellular Location: Membrane; Single-pass type I membrane protein. Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface. Tissue Specificity: Restricted to tissues or cell lines expressing erythroid characters. Post-translational modifications: O-glycosylated. Similarity: Contains 1 Link domain. Database links: Entrez Gene: 10894 Human Entrez Gene: 114332 Mouse Omim: 605702 Human SwissProt: Q9Y5Y7 Human SwissProt: Q8BHC0 Mouse Unigee: 246769 Human Unigene: 655332 Human Unigene: 396078 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
淋巴管系统形成第二循环系统，该循环系统从组织中排出细胞外液体，并提供免疫细胞能够遇到并响应外来抗原的独特环境。近来，许多有趣的分子被鉴定为淋巴管内皮的标志物，包括透明质酸受体LYVE1，PALE，VEGFR3，泊多拉宁。LYVE1是淋巴管壁上HA（细胞外基质糖胺聚糖透明质酸）的主要受体。推导出的LYVE1氨基酸序列预测一个322残基的I型整合膜多肽41％，类似于CD44 HA受体，212残基的胞外结构域包含一个Link模块，Link蛋白超家族的原型HA结合结构域。与CD44一样，LyVE1分子结合可溶性和固定化HA。然而，与CD44不同，LYVE1分子在淋巴管壁的管腔表面与HA共轭，并且完全不存在于血管中。因此，LYVE1是第一个被表征的淋巴特异性HA受体，并且是淋巴管本身的唯一有效的标记。