EDNRA,内皮素受体A抗体

产品编号HZ-1757R
英文名称EDNRA
中文名称内皮素受体A抗体
别 名Endothelin receptor type A; EDNRA; Endothelin 1 receptor precursor; EDNR-A; Endothelin A receptor; Endothelin receptor type A; ET A; ETA; ET-A; ETA-R; ETA R; ETRA; hET AR; Ednra; EDNRA_HUMAN; Endothelin 1 specific receptor; Endothelin ET A receptor; Endothelin receptor ET1 specific type; Endothelin-1 receptor.
说 明 书0.1ml 0.2ml
研究领域心血管 免疫学 生长因子和激素
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
EDNRA,内皮素受体A抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量47kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human EDNRA
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
EDNRA,内皮素受体A抗体PubMedPubMed
产品介绍background:
This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Function:
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

Subunit:
Interacts with HDAC7 and KAT5.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels.

Similarity:
Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.

Gene ID:
1909

EDNRA,内皮素受体A抗体Database links:
Entrez Gene: 281749 Cow
Entrez Gene: 450187 Dog
Entrez Gene: 1909 Human
Entrez Gene: 13617 Mouse
Entrez Gene: 397457 Pig
Entrez Gene: 24326 Rat
GenBank: NM_001957 Human
GenBank: NM_174308 Human
GenBank: NM_012550 Rat
Omim: 131243 Human
SwissProt: P21450 Cow
SwissProt: Q5KSU9 Dog
SwissProt: P25101 Human
SwissProt: Q61614 Mouse
SwissProt: Q29010 Pig
SwissProt: P26684 Rat
Unigene: 183713 Human
Unigene: 283168 Mouse
Unigene: 392296 Mouse
Unigene: 10915 Rat

EDNRA,内皮素受体A抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.