FITC标记的核糖核酸结合蛋白2抗体
产品名称： FITC标记的核糖核酸结合蛋白2抗体
英文名称： Anti-PTBP2/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PTBP2/FITC Conjugated antibody
FITC标记的核糖核酸结合蛋白2抗体
| 英文名称 | Anti-PTBP2/FITC |
| 中文名称 | FITC标记的核糖核酸结合蛋白2抗体 |
| 别 名 | brPTB; FLJ34897; MIBP; Neural polypyrimidine tract binding protein; Neurally enriched homolog of PTB; Polypyrimidine tract binding protein 2; PTB; PTB like; PTB like protein; PTBLP; PTBP 2; PTBP-2; Splicing regulator; PTBP2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Zebrafish, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 57kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PTBP2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: PTBP-2 is a member of the polypyrimidine tract binding family of proteins. Predominantly expressed in brain, but also found in heart and skeletal muscle, PTBP-2 localizes to the nucleus and contains four RRM (RNA recognition motif) domains. PTBP-2 functions as an RNA-binding protein associated in a complex that is involved in the regulation of exon splicing and the stabilization of mRNAs in the cytoplasm. Six isoforms exist for PTBP-2 due to alternative splicing events. Isoforms 1 and 2 (also known as nPTB1 and nPTB2/PTBPLP-L, respectively) are neuronal-specific. Isoforms 3 and 4 (also known as nPTB3/PTBPLP-L and nPTB4, respectively) are found in non-neuronal tissues, as are isoforms 5 and 6 (also known as nPTB5/nPTB7/PTBPLP-S and nPTB6/nPTB8/PTBPLP-S, respectively). The existence of various isoforms may function to modulate the RNA-binding properties of PTBP-2 Function: PTPBP2 is an RNA-binding protein which binds to intronic polypyrimidine tracts. It binds to the CUCUCU splicing repressor element of the downstream control sequence (DCS) and mediates negative regulation of exons splicing. It may also have a role in the regulation of translation. PTBP2 is thought to be involved in the switch to neuronal specific alternative splicing patterns during neuronal differentiation. Subunit: Monomer. Interacts with NOVA1; the interaction is direct. Interacts with NOVA2; the interaction is direct (By similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Part of a ternary complex containing KHSRP and HNRPH1. Subcellular Location: Nuclear Tissue Specificity: Mainly expressed in brain although also detected in other tissues like heart and skeletal muscle. Isoform 1 and isoform 2 are specifically expressed in neuronal tissues. Isoform 3 and isoform 4 are expressed in non-neuronal tissues. Isoform 5 and isoform 6 are truncated forms expressed in non-neuronal tissues. Similarity: Contains 4 RRM (RNA recognition motif) domains. Database links: Entrez Gene: 58155 Human Entrez Gene: 56195 Mouse Entrez Gene: 310820 Rat Omim: 608449 Human SwissProt: Q9UKA9 Human SwissProt: Q91Z31 Mouse SwissProt: Q66H20 Rat Unigene: 269895 Human Unigene: 596061 Human Unigene: 29966 Mouse Unigene: 64916 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
PTBP-2是聚途径结合蛋白家族的成员。PTBP-2主要表达于大脑，也可见于心脏和骨骼肌，定位于细胞核，包含四个RRM（RNA识别基序）结构域。PTBP-2是RNA结合蛋白，与调节外显子剪接和稳定细胞质中的mRNA有关。由于选择性剪接事件，PTBP-2存在六种异构体。异构体1和2（也称为NPTB1和NPTB2/PTBPLP L）分别是神经元特异性的。异型3和4(分别称为nPTB3/PTBPLP-L和nPTB4)在非神经元组织中发现，同型5和6也是如此(分别称为nPTB5/nPTB7/PTBPLP-S和nPTB6/nPTB8/PTBPLP-S)。各种异构体的存在可能调节PTBP-2的RNA结合特性。