LAG-3
产品名称： LAG-3
英文名称： Lymphocyte-activation gene 3
产品编号： HXPR0104-2020001
产品价格： 0
产品产地： 南京
品牌商标： Nanjing Hanxin Pharmaceutical
更新时间： null
使用范围： null
南京汉欣医药科技有限公司
- 联系人 :
- 地址 : 南京市栖霞区仙林街道仙林大学城纬地路9号C5栋
- 邮编 :
- 所在区域 : 江苏
- 电话 : 137****7692 点击查看
- 传真 : 点击查看
- 邮箱 : cassieh@hanxinpharm.com
LAG-3(Lymphocyte-activation gene 3)属于免疫球蛋白超家族，由胞外区、跨膜区和胞质区3个部分组成。它在激活的T细胞和NK细胞中选择性表达。
抑制LAG-3能够让T细胞重新获得细胞毒性，从而增强对肿瘤的杀伤效果。同时抑制LAG-3还能够降低调节T细胞抑制免疫反应的功能。因此，LAG-3被认为是一个比其它免疫检查点蛋白更吸引人的靶点。
汉欣医药提供LAG-3产品，详情如下：
| 蛋白名称 | 规格 | 价格 | 种属 | 蛋白结构 | 理论分子量 | 标签 | 表达系统 | 纯度 |
| LAG3 Protein, Human, His Tag | 50μg | 1200 | Human | Leu 23 - Leu 450 (NP_002277.4) | 47.1kDa | His tag at the C-terminus | HEK293 | SDS-PAGE ≥95% |
| 100μg | 1850 | |||||||
| 200μg | 3000 | |||||||
| 1mg | 7000 特惠 |
纯度
> 95 % as determined by SDS-PAGE.
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
生物活性
Testing in progress
蛋白构建
A DNA sequence encoding the human LAG3 (NP_002277.4) (Met1-Leu450) was expressed with a polyhistidine tag at the C-terminus.
NP No.
NP_002277.4
表达宿主
HEK293 Cells
种属
Human
预测 N 端
Leu 23
分子量
The recombinant human LAG3 consists of 439 amino acids and predicts a molecular mass of 47.1 kDa. As a result of glycosylation, it migrates as an approximately 56.47 KDa band in SDS-PAGE under reducing conditions.
缓冲液
Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of COA.
运输方式
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
稳定性 & 储存条件
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃.
Store it under sterile conditions at -20℃ to -80℃.