FITC标记的可溶性半乳糖凝集素3结合蛋白抗体
产品名称： FITC标记的可溶性半乳糖凝集素3结合蛋白抗体
英文名称： Anti-LGALS3BP/FITC
产品编号： HZ-5729R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-LGALS3BP/FITC Conjugated antibody
FITC标记的可溶性半乳糖凝集素3结合蛋白抗体
| 英文名称 | Anti-LGALS3BP/FITC |
| 中文名称 | FITC标记的可溶性半乳糖凝集素3结合蛋白抗体 |
| 别 名 | Mac 2 binding protein; MAC2BP; Tumor associated antigen 90K; 90K; 90K MAC 2 BP; Basement membrane autoantigen p105; Galectin 3 binding protein; L3 antigen; Lectin galactoside binding soluble 3 binding protein; M2BP; Mac 2 BP; Serum protein 90K; LG3BP_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 细胞周期蛋白 肿瘤细胞生物标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 63kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LGALS3BP |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: LGALS3BP is a ligand of galectin 3, and has been suggested to influence tumor proliferation and metastasis formation. Galectins and their ligands have been implicated in cell transformation and cancer metastasis, and found to have prognostic value. LGALS3BP also known as Mac 2 BP,and as 90K, is a highly glycosylated, secreted protein extensively studied in human cancer, which binds galectin 1, galectin 3 and galectin 7. High expression levels of this molecule are associated with a shorter survival, the occurrence of metastasis or a reduced response to chemotherapy in patients with different types of malignancy. The mechanisms underlying the prognostic significance of 90K and galectins in cancer are far from being understood, although they may be related to the ability of these proteins to interact and, to some extent, modulate cell cell and cell matrix adhesion and apoptosis. Function: Promotes intergrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells. Subunit: Homodimers and homomultimers. Subcellular Location: Secreted. Secreted, extracellular space, extracellular matrix. Tissue Specificity: Ubiquitous. Detected in body fluids such as semen, milk, serum, tears, saliva and urine. Expressed by keratinocytes and fibroblasts. Similarity: Contains 1 BACK (BTB/Kelch associated) domain. Contains 1 BTB (POZ) domain. Contains 1 SRCR domain. Database links: Entrez Gene: 3959 Human Omim: 600626 Human SwissProt: Q08380 Human Unigene: 514535 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
LGALS3BP是半乳糖凝集素3的配体，已被认为影响肿瘤的增殖和转移形成。Galectins及其配体参与了细胞转化和肿瘤转移，具有一定的预后价值。LGALS3BP也被称为MAC 2 bp，和90K，是一种高度糖基化的分泌蛋白，在人类癌症中广泛研究，其结合了半乳糖凝集素1、半乳糖凝集素3和半乳糖凝集素7。这种分子的高表达与不同类型恶性肿瘤患者的生存期短、转移的发生或化疗反应减少有关。90K和半乳糖凝集素在癌症中的预后意义的机制还远未被理解，尽管它们可能与这些蛋白质相互作用的能力有关，并且在一定程度上调节细胞和细胞基质粘附和凋亡。