MAP3K14 (Center) Peptide
产品名称： MAP3K14 (Center) Peptide
英文名称： MAP3K14 (Center) Peptide
产品编号： P2961
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of MAP3K14.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to amino acids 126-155 at internal region of human MAP3K14.
- Host:
- Rabbit
- Reactivity:
- Human, Rat
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Ikappa B kinase 2 but not NF-kappa B-inducing kinase is essential for effective DC antigen presentation in the allogeneic mixed lymphocyte reaction.
Andreakos E, Smith C, Monaco C, Brennan FM, Foxwell BM, Feldmann M.Blood. 2003 Feb 1;101(3):983-91. Epub 2002 Sep 19.
- 2.
- The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway.
Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K.Nature. 1999 Mar 18;398(6724):252-6.
- 3.
- The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17.
Aronsson FC, Magnusson P, Andersson B, Karsten SL, Shibasaki Y, Lendon CL, Goate AM, Brookes AJ.Hum Genet. 1998 Sep;103(3):340-5.
- Applications
- Western Blot
- The MAP3K14 polyclonal antibody (Cat # PAB3183) is used in Western blot to detect MAP3K14 in 293 cell lysate (Lane 1) and rat testis tissue lysate (Lane 2) .
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with MAP3K14 polyclonal antibody (Cat # PAB3183) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma.
- Entrez GeneID:
- 9020
- Protein Accession#:
- M3KE_HUMAN
- Gene Name:
- MAP3K14
- Gene Alias:
- FTDCR1B,HS,HSNIK,NIK
- Gene Description:
- mitogen-activated protein kinase kinase kinase 14
- Omim ID:
- 604655
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq
- Other Designations:
- serine/threonine protein-kinase
- Related Disease