FITC标记的维甲酸诱导蛋白3抗体
产品名称： FITC标记的维甲酸诱导蛋白3抗体
英文名称： Anti-RAI3/FITC
产品编号： HZ-11580R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-RAI3/FITC Conjugated antibody
FITC标记的维甲酸诱导蛋白3抗体
| 产品编号 | bs-11580R-FITC |
| 英文名称 | Anti-RAI3/FITC |
| 中文名称 | FITC标记的维甲酸诱导蛋白3抗体 |
| 别 名 | G protein coupled receptor family C group 5 member A; G-protein coupled receptor family C group 5 member A; GPCR 5A; GPCR5A; Gprc 5a; Gprc5a; Orphan G protein coupling receptor PEIG 1; Orphan G protein coupling receptor PEIG1; Orphan G-protein-coupling receptor PEIG-1; RAI 3; RAI3_HUMAN; Raig 1; RAIG-1; Raig1; Retinoic acid induced 3; Retinoic acid induced gene 1 protein; Retinoic acid induced protein 3; Retinoic acid responsive; Retinoic acid responsive gene; Retinoic acid-induced gene 1 protein; Retinoic acid-induced protein 3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 神经生物学 信号转导 细胞凋亡 G蛋白偶联受体 细胞分化 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 40kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RAI3 (1-33aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: RAI3 is an transmembrane G-protein-coupled receptor that affects many essential biological processes including embryogenesis, cell growth, differentiation, and apoptosis. RAI3 may also be involved in maintaining homeostasis of epithelial cells. Retinoic acid receptors directly regulate RAI3 during its transcription in embryonal carcinoma differentiation. RAI3 expression is upregulated in most tumor cell lines that express mutant p53, suggesting that p53 interacts with the promoter of RAI3 and represses its expression at the beginning of apoptosis. RAI3 is a potential molecular target for diagnosing breast cancer, and selective suppression of signals from RAI3 may have a place in breast cancer treatments. Function: Unknown. This G-protein coupled receptor could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. The comparable expression level in fetal lung and kidney with adult tissues suggests a possible role in embryonic development and maturation of these organs. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Subcellular Location: Cell membrane. Cytoplasmic vesicle membrane. Localized in the plasma membrane and perinuclear vesicles. Tissue Specificity: Expressed at high level in fetal and adult lung tissues. Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small intestine, colon, stomach, and spinal chord at low to moderate levels. Not detectable in fetal heart, brain, and liver and adult heart, brain, liver, skeletal muscle, pancreas, spleen, thymus, and peripheral leukocytes. According to PubMed:10783259, expressed at low but detectable level in pancreas and heart. Similarity: Belongs to the G-protein coupled receptor 3 family. Database links: Entrez Gene: 9052 Human Entrez Gene: 232431 Mouse Entrez Gene: 312790 Rat Omim: 604138 Human SwissProt: Q8NFJ5 Human SwissProt: Q8BHL4 Mouse Unigene: 631733 Human Unigene: 23575 Mouse Unigene: 477015 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
RAI3是一种跨膜G-蛋白偶联受体，影响许多重要的生物学过程，包括胚胎发生、细胞生长、分化和凋亡。RAI3也可能参与维持上皮细胞的稳态。维甲酸受体在胚胎癌分化过程中直接调控RAI3。在表达突变型p53的大多数肿瘤细胞系中，RAI3表达上调，提示p53与RAI3的启动子相互作用，并在凋亡开始时抑制其表达。RAI3是诊断乳腺癌的潜在分子靶点，选择性地抑制RAI3的信号可能在乳腺癌治疗中占有一席之地。