ABL2 polyclonal antibody
产品名称： ABL2 polyclonal antibody
英文名称： ABL2 polyclonal antibody
产品编号： PAB2610
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of ABL2.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to internal region of human ABL2.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Ammonium sulfate precipitation
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Dot Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Catalase is regulated by ubiquitination and proteosomal degradation. Role of the c-Abl and Arg tyrosine kinases.
Cao C, Leng Y, Liu X, Yi Y, Li P, Kufe D.Biochemistry. 2003 Sep 9;42(35):10348-53.
- 2.
- Catalase activity is regulated by c-Abl and Arg in the oxidative stress response.
Cao C, Leng Y, Kufe D.J Biol Chem. 2003 Aug 8;278(32):29667-75. Epub 2003 May 30.
- 3.
- The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases.
Kruh GD, Perego R, Miki T, Aaronson SA.Proc Natl Acad Sci U S A. 1990 Aug;87(15):5802-6.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of ABL2 polyclonal antibody (Cat # PAB2610) in A2058 cell line lysate (35 ug/lane). ABL2 (arrow) was detected using the purified polyclonal antibody (1 : 14 dilution).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with the ABL2 polyclonal antibody (Cat # PAB2610) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
- Entrez GeneID:
- 27
- Protein Accession#:
- NP_009298;P42684
- Gene Name:
- ABL2
- Gene Alias:
- ABLL,ARG,FLJ22224,FLJ31718,FLJ41441
- Gene Description:
- v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
- Omim ID:
- 164690
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinase. The protein is highly similar to the ABL1 protein, including the tyrosine kinase, SH2 and SH3 domains, and has a role in cytoskeletal rearrangements by its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ETV6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- Abelson murine leukemia viral (v-abl) oncogene homolog 2,Abelson-related gene protein,OTTHUMP00000033139,arg tyrosine kinase,v-abl Abelson murine leukemia viral oncogene homolog 2
- Interactome
- Gene Pathway