FITC标记的前列腺特异膜抗原抗体
产品名称： FITC标记的前列腺特异膜抗原抗体
英文名称： Anti-PSMA/FITC
产品编号： HZ-2899R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-PSMA/FITC Conjugated antibody
FITC标记的前列腺特异膜抗原抗体
| 英文名称 | Anti-PSMA/FITC |
| 中文名称 | FITC标记的前列腺特异膜抗原抗体 |
| 别 名 | FOLH; PMSA; Cell growth inhibiting protein 27; FGCP; Folate hydrolase 1; folate hydrolase; Folate hydrolase prostate specific membrane antigen 1; FOLH 1; FOLH; FOLH1; Folylpoly gamma glutamate carboxypeptidase; GCP 2; GCP II; GCP2; GCPII; glutamate carboxylase II; Glutamate carboxypeptidase 2; glutamate carboxypeptidase II; Membrane glutamate carboxypeptidase; mGCP; N acetylated alpha linked acidic dipeptidase 1; N acetylated alpha linked acidic dipeptidase I; NAALAD 1; NAALAD1; NAALAdase; NAALADase I; prostate specific membrane antigen; PSM; pteroylpoly gamma glutamate carboxypeptidase; FOLH1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 细胞表面分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 84kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PSMA |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: PMSA (FOLH1) is a type II transmembrane glycoprotein belonging to the M28 peptidase family. Three functionally distinct proteins are encoded, including folylpoly-gamma-glutamate carboxypeptidase in the intestine, N-acetylated alpha-linked acidic dipeptidase 1 in the brain, and prostate-specific membrane antigen in the prostate. A mutation in the intestinal form may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. The form expressed in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. The prostate form is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants. Subunit: Homodimer. Subcellular Location: Cell membrane; Single-pass type II membrane protein. Isoform PSMA': Cytoplasm. Tissue Specificity: Highly expressed in prostate epithelium. Detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). Detected in the small intestine, brain, kidney, liver, spleen, colon, trachea, spinal cord and the capillary endothelium of a variety of tumors. Expressed specifically in jejunum brush border membranes. In the brain, highly expressed in the ventral striatum and brain stem. Also expressed in fetal liver and kidney. Isoform PSMA' is the most abundant form in normal prostate. Isoform PSMA-1 is the most abundant form in primary prostate tumors. Isoform PSMA-2 is also found in normal prostate as well as in brain and liver. Isoform PSMA-9 is specifically expressed in prostate cancer. Similarity: Belongs to the peptidase M28 family. M28B subfamily. Database links: Entrez Gene: 2346 Human Omim: 600934 Human SwissProt: Q04609 Human Unigene: 654487 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
PMSA（FALH1）是属于M28肽酶家族的II型跨膜糖蛋白。编码三种功能不同的蛋白质，包括肠道中的Faly-聚γ-谷氨酸羧肽酶、脑中N-乙酰化的α-连接的酸性二肽酶1和前列腺中的前列腺特异性膜抗原。肠道形式的突变可能与膳食叶酸的肠道吸收受损有关，导致低血叶酸水平和随之产生的高同型半胱氨酸血症。在大脑中表达的形式可能参与了与谷氨酸兴奋毒性相关的许多病理条件。前列腺形态在癌细胞中被上调，被用作前列腺癌的有效诊断和预后指标。这种基因可能是由邻近染色体区域的复制事件引起的。选择性剪接导致多个转录变体。