FITC标记的防御素β-121/β-defensin 121抗体
产品名称： FITC标记的防御素β-121/β-defensin 121抗体
英文名称： Anti-DEFB121/FITC
产品编号： HZ-14251R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-DEFB121/FITC Conjugated antibody
FITC标记的防御素β-121/β-defensin 121抗体
| 英文名称 | Anti-DEFB121/FITC |
| 中文名称 | FITC标记的防御素β-121/β-defensin 121抗体 |
| 别 名 | beta 121; Beta-defensin 121; Beta-defensin 21; DB121_HUMAN; DEFB-21; DEFB121; Defensin; defensin, beta 121; defensin, beta 21; ESC42RELC. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 发育生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 6.8kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DEFB121 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Beta-defensins are small cationic peptides with broad-spectrum antimicrobial activity against a variety of enveloped viruses, fungi and bacteria. Produced in mucosal epithelia and neutrophils of several species, Beta-defensins are developmentally regulated. The family of Beta-defensin proteins share a common defensin-motif that is characterized by multiple cysteine residues and a highly conserved tertiary structure. Besides playing a significant role in host immune defense, many Beta-defensins also are involved in sperm maturation and capacitation. Beta-defensin 121 is a 76 amino acid secreted protein that most likely contains a signal peptide sequence that requires cleavage by proteolytic enzymes in order to become biologically active. While expressed at low levels in testis, Beta-defensin 121 is abundantly expressed in epididymal caput and corpus and, unlike other Beta-defensins, it does not appear to be regulated by androgens. Function: Has antibacterial activity. Subcellular Location: Secreted. Similarity: Belongs to the beta-defensin family. Database links: Entrez Gene: 245934 Human SwissProt: Q5J5C9 Human Unigene: 272294 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
β-防御素是一种具有广谱抗菌活性的小型阳离子肽，对多种包膜病毒、真菌和细菌均有抑制作用。在几种上皮细胞的粘膜上皮和中性粒细胞中，β防御素是发育调节的。β-防御素蛋白家族具有共同的防御素基序，其特点是具有多个半胱氨酸残基和高度保守的三级结构。除了在宿主免疫防御中发挥重要作用，许多β-防御素还参与精子的成熟和获能。β-防御素121是一种76个氨基酸分泌的蛋白质，它很可能含有一个信号肽序列，该序列需要通过蛋白水解酶裂解才能变得具有生物活性。β-防御素121在睾丸中低水平表达，但在附睾头和附睾体大量表达，与其他β-防御素不同，它似乎不受雄激素调节。