FITC标记的转导素β1X连锁蛋白抗体
产品名称： FITC标记的转导素β1X连锁蛋白抗体
英文名称： Anti-TBL1X/SMAP55/FITC
产品编号： HZ-4219R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-TBL1X/SMAP55/FITC Conjugated antibody
FITC标记的转导素β1X连锁蛋白抗体
| 英文名称 | Anti-TBL1X/SMAP55/FITC |
| 中文名称 | FITC标记的转导素β1X连锁蛋白抗体 |
| 别 名 | TBL1; EBI; F box like/WD repeat protein TBL1X; SMAP 55; SMAP55; TBL 1; TBL1X; Transducin (beta) like 1; Transducin (beta) like 1 X linked; Transducin beta like 1 X linked; Transducin beta like 1X; Transducin beta like 1X protein; TBL1X_HUMAN; F-box-like/WD repeat-containing protein TBL1X; Full=Transducin beta-like protein 1X; Transducin-beta-like protein 1, X-linked. . |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 染色质和核信号 神经生物学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 63kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TBL1X |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene. [provided by RefSeq]. Function: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange. Subunit: Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Probably part of other corepressor complexes, that do not contain NCOR1 and NCOR2. Interacts with histones H2B, H3a and H4. Subcellular Location: Nucleus (Probable). Tissue Specificity: Ubiquitous. Similarity: Belongs to the WD repeat EBI family. Contains 1 F-box-like domain. Contains 1 LisH domain. Contains 8 WD repeats. Database links: Entrez Gene: 426045 Chicken Entrez Gene: 515972 Cow Entrez Gene: 6907 Human Entrez Gene: 21372 Mouse Entrez Gene: 302711 Rat Entrez Gene: 560294 Zebrafish Omim: 300196 Human SwissProt: O60907 Human SwissProt: Q9QXE7 Mouse Unigene: 495656 Human Unigene: 258476 Mouse Unigene: 107002 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
由该基因编码的蛋白质具有与含有蛋白质家族的WD40重复序列的序列相似性。WD40组是一大家族的蛋白质，其似乎具有调节功能。据认为，WD40重复介导的蛋白质-蛋白质相互作用，家庭成员参与信号转导，RNA处理，基因调控，囊泡运输，细胞骨架装配，并可能发挥控制细胞分化的作用。该编码蛋白被发现为辅阻遏SMRT（沉默类介导维甲酸和甲状腺受体）复合物与组蛋白脱乙酰基酶3蛋白的亚基。该基因定位于眼白化病基因，并被认为参与了迟发性感音神经性耳聋表型的白化病的发病机制。四个转录变体，编码两种不同的异构体已经发现这个基因。该基因与Y染色体TBL1Y基因高度相似。[由RefSeq提供]。