FITC标记的螺旋环螺旋蛋白1+2抗体
产品名称： FITC标记的螺旋环螺旋蛋白1+2抗体
英文名称： Anti-NHLH1 + NHLH2/FITC
产品编号： HZ-11523R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-NHLH1 + NHLH2/FITC Conjugated antibody
FITC标记的螺旋环螺旋蛋白1+2抗体
| 产品编号 | bs-11523R-FITC |
| 英文名称 | Anti-NHLH1 + NHLH2/FITC |
| 中文名称 | FITC标记的螺旋环螺旋蛋白1+2抗体 |
| 别 名 | HEN1; HEN2; Nescient helix loop helix 1; HEN1_HUMAN . Nescient helix loop helix 2; NSCL; NSCL1; NSCL2; HEN2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 神经生物学 信号转导 转录调节因子 细胞膜受体 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 15kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NHLH1 + NHLH2 (91-133aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The helix-loop-helix (HLH) structures are known motifs commonly found in membrane-active and DNA-binding proteins. The helix-loop-helix proteins HEN1 and HEN2 are DNA-binding proteins that may be involved in cell-type determination in the early nervous system. Studies of expression in normal tissues have demonstrated expression of NHLH1/NSCL-1 and NHLH2/NSCL-2, the genes encoding HEN1 and HEN2, in the developing central and peripheral nervous system, specifically in developing neurons. Function: NHLH1 and NHLH2 are two basic domain helix-loop-helix (bHLH) proteins expressed predominantly in the developing nervous system and also in some cell lines derived from tumors with neural or neuroendocrine features such as neuroblastoma, PNET, and small cell lung cancer. Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Subcellular Location: Nucleus Similarity: Contains 1 bHLH (basic helix-loop-helix) domain. Database links: Entrez Gene: 4807 Human Entrez Gene: 4808 Human Entrez Gene: 18071 Mouse Entrez Gene: 18072 Mouse Omim: 162360 Human Omim: 162361 Human SwissProt: Q02575 Human SwissProt: Q02577 Human SwissProt: Q02576 Mouse SwissProt: Q64221 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
螺旋环螺旋（HLH）结构是常见于膜活性和DNA结合蛋白中的已知基序。螺旋环螺旋蛋白HeN1和HeN2是可能参与早期神经系统细胞类型测定的DNA结合蛋白。在正常组织中的表达研究表明，NHLH1/NSCL-1和NHLH2/NSL2的表达，编码HEN1和HN2的基因，在发展的中枢神经系统和外周神经系统，特别是在发育中的神经元。