FITC标记的白细胞衍生化学吸引素抗体
产品名称： FITC标记的白细胞衍生化学吸引素抗体
英文名称： Anti-LECT1/FITC
产品编号： HZ-7516R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-LECT1/FITC Conjugated antibody
FITC标记的白细胞衍生化学吸引素抗体
| 英文名称 | Anti-LECT1/FITC |
| 中文名称 | FITC标记的白细胞衍生化学吸引素抗体 |
| 别 名 | Chondromodulin I; BRICD3; BRICHOS domain containing 3; CHM I; CHM1; chondromodulin; Chondrosurfactant protein; LECT 1; Leukocyte cell derived chemotaxin 1; LECT1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 心血管 细胞生物 免疫学 细胞周期蛋白 细胞骨架 细胞外基质 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Guinea Pig, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 14kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LECT1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The LECT1 gene encodes a glycosylated transmembrane protein which is cleaved to form a mature, secreted protein. The N terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein, although no biological activity has yet been defined for it. The C terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell derived chondromodulin 1 or chemotaxin 1. The mature protein inhibits angiogenesis and promotes chondrocyte growth. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms. Function: Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Subcellular Location: Chondromodulin-1: Secreted. Note=Accumulated in the inter-territorial matrix of cartilage. Chondrosurfactant protein: Endomembrane system; Single-pass membrane protein (Potential). Tissue Specificity: Cartilage specific. Weakly expressed in chondrosarcoma. Similarity: Belongs to the chondromodulin-1 family. Contains 1 BRICHOS domain. Database links: UniProtKB/Swiss-Prot: O75829.1
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
LTEC1基因编码糖化的跨膜蛋白，其裂解形成成熟分泌蛋白。前体蛋白的N端与其他表面活性剂蛋白共享特征，有时被称为软骨表面活性蛋白，尽管尚未确定其生物活性。前体蛋白的C末端含有25 kDa成熟蛋白，称为白细胞衍生的软骨调节蛋白1或趋化因子1。成熟蛋白抑制血管生成，促进软骨细胞生长。该基因在肥大软骨的无血管区表达，在软骨细胞肥大和血管侵犯中表达减少。成熟的蛋白质可能在软骨内骨发育中起作用，允许软骨性血管被血管化并被骨替代。在发展过程中，它也可能参与组织血管化的广泛控制。选择性剪接导致多个转录子变体编码不同的亚型。