FITC标记的标记小鼠抗人CD25单克隆抗体
产品名称： FITC标记的标记小鼠抗人CD25单克隆抗体
英文名称： Anti-human CD25-PEPE/FITC
产品编号： HZ-30077M-PE-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200
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Mouse Anti-human CD25-PEPE/FITC Conjugated antibody
FITC标记的标记小鼠抗人CD25单克隆抗体
| 英文名称 | Anti-human CD25-PEPE/FITC |
| 中文名称 | FITC标记的标记小鼠抗人CD25单克隆抗体 |
| 别 名 | Interleukin 2 receptor alpha chain; CD 25; CD25; CD25 antigen; IDDM10; IL 2 RA; IL 2 receptor alpha subunit; IL2 RA; IL-2RA; IL2R; IL2RA; IL2RAC; Interleukin 2 Receptor Alpha; Interleukin 2 receptor alpha chain; Interleukin 2 receptor; Ly43; p55; T Cell Growth Factor Receptor; TAC Antigen; TCGFR; IL2RA_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 细胞膜受体 淋巴细胞 t-淋巴细胞 b-淋巴细胞 |
| 抗体来源 | Mouse |
| 克隆类型 | Monoclonal |
| 交叉反应 | Human, |
| 产品应用 | Flow-Cyt=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 28kDa |
| 性 状 | Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein G |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]. Function: Receptor for interleukin-2. Subunit: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Subcellular Location: Membrane; Single-pass type I membrane protein. Similarity: Contains 2 Sushi (CCP/SCR) domains. Database links: Entrez Gene: 3559 Human SwissProt: P01589 Human Unigene: 231367 Human Omim: 147730 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
由该基因编码的蛋白质是白介素7（IL7）的受体。该受体的功能需要白细胞介素2受体，γ链（IL2RG），它是由各种细胞因子受体（包括白介素2, 4, 7、9和15）共同共享的共同γ链。这种蛋白已被证明在淋巴细胞发育过程中V（D）J重组中起关键作用。还发现该蛋白通过STAT5和组蛋白乙酰化来控制TCRγ位点的可访问性。敲除小鼠的研究表明阻断凋亡是T淋巴细胞分化和活化过程中蛋白质的基本功能。该蛋白的功能缺陷可能与重度联合免疫缺陷（SCID）发病相关。