KCNE1 Validated Chimera RNAi
产品名称： KCNE1 Validated Chimera RNAi
英文名称： KCNE1 Validated Chimera RNAi
产品编号： H00003753-R01V
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Homo sapiens potassium voltage-gated channel, Isk-related family, member 1 (KCNE1), mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_000219
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Applications
- RNAi Knockdown (Antibody validated)
- Western blot analysis of KCNE1 over-expressed 293 cell line, cotransfected with KCNE1 Validated Chimera RNAi ( Cat # H00003753-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with KCNE1 monoclonal antibody (M01), clone 5B12 (Cat # H00003753-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
- Protocol Download
- Entrez GeneID:
- 3753
- Gene Name:
- KCNE1
- Gene Alias:
- FLJ18426,FLJ38123,FLJ94103,ISK,JLNS,JLNS2,LQT2/5,LQT5,MGC33114,MinK
- Gene Description:
- potassium voltage-gated channel, Isk-related family, member 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq
- Other Designations:
- IKs producing slow voltage-gated potassium channel subunit beta Mink,OTTHUMP00000108623,OTTHUMP00000108625,OTTHUMP00000108626,cardiac delayed rectifier potassium channel protein,delayed rectifier potassium channel subunit IsK,minimal potassium channel,pot
- Related Disease
- Arrhythmia
- Arrhythmias, Cardiac
- Atrial Fibrillation
- Atrioventricular Block
- Brugada Syndrome
- Cardiomyopathies
- Cardiovascular Diseases
- Channelopathies
- Chromosome Deletion
- Cognition
- Death, Sudden
- Death, Sudden, Cardiac
- Diabetes Mellitus, Type 2
- Edema
- Gastroparesis
- Genetic Predisposition to Disease
- Hearing Loss
- Hearing Loss, Noise-Induced
- Heart Arrest