FITC标记的DENND4A蛋白抗体
产品名称： FITC标记的DENND4A蛋白抗体
英文名称： Anti-DENND4A/FITC
产品编号： HZ-14272R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-DENND4A/FITC Conjugated antibody
FITC标记的DENND4A蛋白抗体
| 英文名称 | Anti-DENND4A/FITC |
| 中文名称 | FITC标记的DENND4A蛋白抗体 |
| 别 名 | C-myc promoter-binding protein; DENN domain-containing protein 4A; DENN/MADD domain containing 4A; DENND4A; FLJ33949; IRLB; KIAA0476; MYCPBP; MYCPP_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 转运蛋白 结合蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 209kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DENND4A |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Encoding more than 700 genes, chromosome 15 is made up of approximately 106 million base pairs and is about 3% of the human genome. Angelman and Prader-Willi syndromes are associated with loss of function or deletion of genes in the 15q11-q13 region. In the case of Angelman syndrome, this loss is due to inactivity of the maternal 15q11-q13 encoded UBE3A gene in the brain by either chromosomal deletion or mutation. In cases of Prader-Willi syndrome, there is a partial or complete deletion of this region from the paternal copy of chromosome 15. Tay-Sachs disease is a lethal disorder associated with mutations of the HEXA gene, which is encoded by chromosome 15. Marfan syndrome is associated with chromosome 15 through the FBN1 gene. Function: Binds to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. Subcellular Location: Nucleus. Tissue Specificity: Expressed ubiquitously. Highest expression in bone marrow, medium in peripheral blood lymphocytes and lowest in spleen. In brain, breast, and prostate, higher expression was seen in normal cells than in tumor cells. Expression is regulated in a growth- and cell cycle-dependent manner. Similarity: Contains 1 dDENN domain. Contains 1 DENN domain. Contains 1 MABP domain. Contains 2 PPR (pentatricopeptide) repeats. Contains 1 uDENN domain. Database links: Entrez Gene: 10260 Human Omim: 600382 Human SwissProt: Q7Z401 Human Unigene: 654567 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
染色体15编码700多个基因，由大约1.06亿个碱基对组成，约占人类基因组的3%。Angelman和Prader Willi综合征与15q11-q13区域的功能丧失或基因缺失有关。对于Angelman综合征，这种丢失是由于母体15q11-q13编码的UBE3A基因在大脑中通过染色体缺失或突变而失活造成的。在Prader-Willi综合征的病例中，15号染色体的父本拷贝中有一部分或完全缺失。Tay-Sachs病是与15号染色体编码的HEXA基因突变相关的致死性疾病。MfFe综合征通过FBN1基因与15号染色体相关。