FITC标记的脆性组氨酸三联体抗体
产品名称： FITC标记的脆性组氨酸三联体抗体
英文名称： Anti-FHIT/FITC
产品编号： HZ-1769R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-FHIT/FITC Conjugated antibody
FITC标记的脆性组氨酸三联体抗体
| 英文名称 | Anti-FHIT/FITC |
| 中文名称 | FITC标记的脆性组氨酸三联体抗体 |
| 别 名 | fragile histidine triad; AP3A hydrolase; AP3A hydrolase fragile site 3p14.2; AP3Aase; Bis 5' adenosyl triphosphatase; Dinucleosidetriphosphatase; FRA 3B; FRA3B; Fragile histidine triad gene; Fragile histidine triad protein; Tumor suppressor protein; FHIT_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 17kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FHIT |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.[provided by RefSeq, Feb 2011] Function: Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. Subunit: Homodimer. Subcellular Location: Cytoplasm. Tissue Specificity: Low levels expressed in all tissues tested. Phospho-FHIT observed in liver and kidney, but not in brain and lung. Phospho-FHIT undetected in all tested human tumor cell lines. DISEASE: Glycogen storage disease 1A (GSD1A) [MIM:232200]: A metabolic disorder characterized by impairment of terminal steps of glycogenolysis and gluconeogenesis. Patients manifest a wide range of clinical symptoms and biochemical abnormalities, including hypoglycemia, severe hepatomegaly due to excessive accumulation of glycogen, kidney enlargement, growth retardation, lactic acidemia, hyperlipidemia, and hyperuricemia. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Contains 1 HIT domain. Database links: Entrez Gene: 2272 Human Entrez Gene: 14198 Mouse Entrez Gene: 60398 Rat Omim: 601153 Human SwissProt: P49789 Human SwissProt: O89106 Mouse SwissProt: Q9JIX3 Rat Unigene: 655995 Human Unigene: 441926 Mouse Unigene: 45598 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 脆性组氨酸三联体（FHIT）作为肿瘤抑制因子发挥作用，其基因的突变和缺失与人类一系列肿瘤的发生和发展密切相关。这些肿瘤发生部位包括肺、头颈部、乳腺、结肠、胃以及胰腺 |
葡萄糖-6-磷酸酶(G6Pase)是内质网的多亚基整合膜蛋白，由G6P、无机磷酸盐和葡萄糖的催化亚基和转运体组成。该基因（G6PC）是三个葡萄糖-6-磷酸酶催化亚基编码基因之一：G6PC、G6PC2和G6PC3。葡萄糖-6-磷酸酶催化D-葡萄糖6-磷酸水解成D-葡萄糖和正磷酸盐，是葡萄糖稳态的关键酶，具有糖异生和糖原分解的功能。该基因的突变导致I型糖原贮积病（GSD1）。这种疾病也称为von Gierke病，是一种代谢紊乱，特征是严重的低血糖，与肝和肾中糖原和脂肪的积累有关。