CBL monoclonal antibody, clone M159
产品名称： CBL monoclonal antibody, clone M159
英文名称： CBL monoclonal antibody, clone M159
产品编号： MAB1378
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against synthetic peptide of CBL.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human CBL.
- Host:
- Mouse
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- This sequence is highly conserved in rat and mouse c-Cbl.
- Form:
- Liquid
- Isotype:
- IgG1
- Storage Buffer:
- In PBS (50% glycerol, 1 mg/mL BSA, 0.05% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:2000)
Western Blot (1:500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Cbl: many adaptations to regulate protein tyrosine kinases.
Thien CB, Langdon WY.Nat Rev Mol Cell Biol. 2001 Apr;2(4):294-307.
- 2.
- The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor.
Donovan JA, Wange RL, Langdon WY, Samelson LE.J Biol Chem. 1994 Sep 16;269(37):22921-4.
- 3.
- Physical association between Src homology 3 elements and the protein product of the c-cbl proto-oncogene.
Rivero-Lezcano OM, Sameshima JH, Marcilla A, Robbins KC.J Biol Chem. 1994 Jul 1;269(26):17363-6.
- Entrez GeneID:
- 867
- Protein Accession#:
- P22681
- Gene Name:
- CBL
- Gene Alias:
- C-CBL,CBL2,RNF55
- Gene Description:
- Cas-Br-M (murine) ecotropic retroviral transforming sequence
- Omim ID:
- 165360
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. [provided by RefSeq
- Other Designations:
- oncogene CBL2