FITC标记的PSPC1蛋白抗体
产品名称： FITC标记的PSPC1蛋白抗体
英文名称： Anti-PSPC1/FITC
产品编号： HZ-7480R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PSPC1/FITC Conjugated antibody
FITC标记的PSPC1蛋白抗体
| 英文名称 | Anti-PSPC1/FITC |
| 中文名称 | FITC标记的PSPC1蛋白抗体 |
| 别 名 | Paraspeckle component 1; Paraspeckle protein 1; PSP1; Pspc1; PSPC1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Chinese Hamster, Bat, Elephant |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 59kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PSPC1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified. [provided by RefSeq, Aug 2011] Function: Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line. Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Subcellular Location: Nucleus > nucleolus. Nucleus matrix. Cytoplasm. In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in a RNA-dependent manner. May cycles between paraspeckles and nucleolus. In telophase, when daughter nuclei form, localizes to perinucleolar caps. Tissue Specificity: Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the PSPC family. Contains 2 RRM (RNA recognition motif) domains. Database links: Entrez Gene: 55269 Human Entrez Gene: 66645 Mouse Entrez Gene: 305910 Rat SwissProt: Q1LZD9 Cow SwissProt: Q8WXF1 Human SwissProt: Q8R326 Mouse SwissProt: Q4KLH4 Rat Unigene: 213198 Human Unigene: 20129 Mouse Unigene: 140724 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
这种基因编码一种核仁蛋白，定位于点状亚核结构，这种亚核结构发生在拼接斑点附近，称为副斑点。这些副斑是由包括非编码RNA、NEAT1/Menε/β和果蝇行为人类剪接蛋白家族的RNA-蛋白质结构组成，该家族包括该基因和P54NRB/NONO和PSF/SFPQ蛋白的产物。副核糖可能通过RNA核保持机制在基因表达的控制中起作用。该基因编码的蛋白质存在于转录活性细胞中的旁棘中，但是当RNA聚合酶II转录被抑制时，或在末期时，它定位于核仁周边独特的帽状结构。该基因的选择性剪接导致多个转录变体。一个相关的假基因，也位于13号染色体上，已经被鉴定出来。[ RefSeq，Aug 2011提供]