FITC标记的细胞膜钙转运ATP酶抗体
产品名称： FITC标记的细胞膜钙转运ATP酶抗体
英文名称： Anti-PMCA2/FITC
产品编号： HZ-6499R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-PMCA2/FITC Conjugated antibody
FITC标记的细胞膜钙转运ATP酶抗体
| 产品编号 | bs-6499R-FITC |
| 英文名称 | Anti-PMCA2/FITC |
| 中文名称 | FITC标记的细胞膜钙转运ATP酶抗体 |
| 别 名 | ATP2B1; ATP2B2; ATP2B3; ATP2B4; ATPase Ca++ transporting plasma membrane 1; ATPase Ca++ transporting plasma membrane 2; ATPase Ca++ transporting plasma membrane 3; ATPase Ca++ transporting plasma membrane 4; Plasma membrane calcium transporting ATPase 1; Plasma membrane calcium transporting ATPase 2; Plasma membrane calcium transporting ATPase 3; Plasma membrane calcium transporting ATPase 4; PMCA1; PMCA2; PMCA3; PMCA4; AT2B2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 信号转导 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 137kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PMCA |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Plasma membrane-type Ca2+-ATPases (PMCAs) mediate the export of bivalent calcium ions from eukaryotic cells. As members of the P class of ion-motive ATPases, PMCAs are a functionally diverse group of proteins that are derived from alternatively spliced transcripts originating from at least four distinct genes. The expression of different PMCA isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, and with respect to the physiological needs of specific cell and tissue types. Spatial and temporal rates of resting intracellular Ca2+ concentrations and Ca2+ signaling in eukaryotic cells are dependent on the array of PMCA isoforms that are expressed in concert with the rate of Ca2+ export. Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Mainly expressed in brain cortex. Found in low levels in skeletal muscle, heart muscle, stomach, liver, kidney and lung. Isoforms containing segment B are found in brain cortex and at low levels in other tissues. Isoforms containing segments X and W are found at low levels in all tissues. Isoforms containing segment A and segment Z are found at low levels in skeletal muscle and heart muscle. Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. Database links: Entrez Gene: 491 Human Entrez Gene: 11941 Mouse Entrez Gene: 24215 Rat Omim: 108733 Human SwissProt: Q01814 Human SwissProt: Q9R0K7 Mouse SwissProt: P11506 Rat Unigene: 268942 Human Unigene: 321755 Mouse Unigene: 90982 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
质膜型Ca2+ - ATPases（PCAMAs）介导了真核细胞中的二价钙离子的输出。作为P类离子运动ATP酶的成员，PMCAs是从至少四个不同基因起源的交替剪接转录产物衍生的功能多样的蛋白质组。不同的PMCA亚型和剪接变异体的表达在发育、组织和细胞类型特定的方式中被调节，并且相对于特定细胞和组织类型的生理需要进行调节。静止细胞内Ca2+浓度和Ca2+信号在真核细胞中的时空速率依赖于与Ca2+输出速率一致表达的PMCA亚型阵列。