FITC标记的肌细胞增强因子2B抗体
产品名称： FITC标记的肌细胞增强因子2B抗体
英文名称： Anti-MEF2B/FITC
产品编号： HZ-9470R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-MEF2B/FITC Conjugated antibody
FITC标记的肌细胞增强因子2B抗体
| 产品编号 | bs-9470R-FITC |
| 英文名称 | Anti-MEF2B/FITC |
| 中文名称 | FITC标记的肌细胞增强因子2B抗体 |
| 别 名 | PRDM3; MADS box transcription enhancer factor 2; MDS1 EVI1; Mef2b; MEF2B_HUMAN; MEF-2B; myocyte enhancer factor 2B; myocyte specific enhancer factor 2B; Myocyte-specific enhancer factor 2B; RSRFR2; serum response factor like protein 2; Serum response factor-like protein 2; XMEF2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 细胞生物 神经生物学 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 39kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MEF2B |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The myocyte enhancer factor-2 (MEF-2) family of transcription factors associate with co-repessors or co-activators to regulate development and function of T cells, neuronal cells, and muscle cells. Four family members, termed MEF-2A, -2B, -2C, and -2D, arise from alternatively spliced transcripts. These members bind as homo- and heterodimers to the MEF-2 site in the promoter region of affected genes. Differential regulation in the expression of the four transcripts implies functional distinction for each during embryogenesis and development. The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including MyoD, myogenin, Myf-5, and MRF4, are one class of identified factors. The MEF-2 family represents a second class of DNA binding regulatory proteins. Each of these proteins binds to the MEF-2 target DNA sequence present in the regulatory regions of many muscle-specific genes. Function: Transcriptional activator which binds specifically tothe MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerousmuscle-specific genes. Activates transcription via this element.May be involved in muscle-specific and/or growth factor-relatedtranscription. Subunit: Interacts with HDAC7 (By similarity). Heterodimer.Interacts with HDAC9. Subcellular Location: Nucleus. Tissue Specificity: Expressed in skeletal and cardiac muscle and brain. Similarity: Belongs to the MEF2 family. Contains 1 MADS-box domain. Contains 1 Mef2-type DNA-binding domain. Database links: Entrez Gene: 4207 Human Entrez Gene: 17259 Mouse Omim: 600661 Human SwissProt: Q02080 Human SwissProt: O55087 Mouse Unigene: 153629 Human Unigene: 432505 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
肌细胞增强子-2（MEF-2）家族的转录因子与共刺激因子或共激活物相关，以调节T细胞、神经元细胞和肌肉细胞的发育和功能。四个家庭成员，被称为MEF-2A，-2B，-2C，和-2D，来自交替剪接转录本。这些成员作为同源基因和异源二聚体结合到受影响基因的启动子区域中的MEF-2位点。在四个转录表达的差异调节意味着每个胚胎发育和发育的功能区分。从中胚层前体细胞向成肌细胞分化的过程导致发现了多种调节肌肉基因表达的组织特异性因子。肌源性碱性螺旋环螺旋蛋白，包括Myod、MyoGIN、MYF-5和MRF4，是一类被鉴定的因子。MEF-2家族代表第二类DNA结合调节蛋白。这些蛋白中的每一个都与存在于许多肌肉特异基因的调控区中的MEF-2靶DNA序列结合。