FAM3B,胰腺衍生因子抗体

产品编号HZ-0711R
英文名称FAM3B
中文名称胰腺衍生因子抗体
别 名C21orf11; PANDER; Cytokine like protein 2 21; PRED44; PANcreatic DERived factor; Protein FAM3B; Protein FAM3B precursor; Family with sequence similarity 3, member B isoform a; FAM3B_MOUSE.
说 明 书0.1ml 0.2ml
研究领域免疫学 细胞凋亡 糖尿病
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat,
FAM3B,胰腺衍生因子抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量23kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human FAM3B
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
FAM3B,胰腺衍生因子抗体PubMedPubMed
产品介绍background:
FAM3B has delayed effects on beta-cell function, inhibiting basal insulin secretion from a beta-cell line in a dose-dependent manner. [Subcellular Location] Secreted. Note=Localized in discrete vesicular and perinuclear structure. Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis. 2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46. Belongs to the FAM3 family.

Function:
Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.

Subcellular Location:
Secreted. Note=Present in insulin secretory granules and likely cosecreted with insulin. Localized in discrete vesicular and perinuclear structure.

Tissue Specificity:
Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis.

Post-translational modifications:
2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46.
O-glycosylated.

FAM3B,胰腺衍生因子抗体Similarity:
Belongs to the FAM3 family.

Gene ID:
52793

Database links:
Entrez Gene: 54097 Human
Entrez Gene: 52793 Mouse
Omim: 608617 Human
SwissProt: P58499 Human
SwissProt: Q9D309 Mouse
Unigene: 473877 Human
Unigene: 670704 Human
Unigene: 327932 Mouse

FAM3B,胰腺衍生因子抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

胰腺衍生因子（PANcreatic DERived fa*ctor，PANDER）是新发现的一种新型的胰岛细胞因子、由胰岛α细胞和β细胞分泌的一种分泌型细胞因子，与β细胞凋亡密切相关 ，可以诱导胰岛素分泌β细胞，主要用于糖尿病的研究。

产品图片

Tissue/cell: rat pancreas tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;  Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;  Incubation: Anti-FAM3B/PANDER Polyclonal Antibody, Unconjugated(HZ-0711R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining