PLCG1 polyclonal antibody
产品名称： PLCG1 polyclonal antibody
英文名称： PLCG1 polyclonal antibody
产品编号： PAB18129
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of PLCG1.
- Immunogen:
- A synthetic peptide corresponding to human PLCG1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- This antibody is specific to PLCG1.
- Form:
- Liquid
- Purification:
- Affinity purification
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Effects of adenylyl cyclase and protein kinase A inhibition on signaling enzymes in natural killer cells: comparison to tributyltin.
Whalen MM, Odman-Ghazi SO.Hum Exp Toxicol. 2006 Jun;25(6):333-40.
- 2.
- Integrin-dependent PLC-gamma1 phosphorylation mediates fibronectin-dependent adhesion.
Tvorogov D, Wang XJ, Zent R, Carpenter G.J Cell Sci. 2005 Feb 1;118(Pt 3):601-10. Epub 2005 Jan 18.
- 3.
- Pleiotropic contributions of phospholipase C-gamma1 (PLC-gamma1) to T-cell antigen receptor-mediated signaling: reconstitution studies of a PLC-gamma1-deficient Jurkat T-cell line.
Irvin BJ, Williams BL, Nilson AE, Maynor HO, Abraham RT.Mol Cell Biol. 2000 Dec;20(24):9149-61.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of extracts from 293 cells, treated with EGF (200 ng/mL, 30 mins), using PLCG1 polyclonal antibody (Cat # PAB18129).
Peptide "+" means "peptide blocking".
- Entrez GeneID:
- 5335
- Protein Accession#:
- P19174
- Gene Name:
- PLCG1
- Gene Alias:
- PLC-II,PLC1,PLC148,PLCgamma1
- Gene Description:
- phospholipase C, gamma 1
- Omim ID:
- 172420
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate,1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1,OTTHUMP00000031787,OTTHUMP00000178982,PLC-gamma-1,inositoltrisphosphohydrolase,monophosphatidylinositol phosphodiesterase,phosphatidylinositol
- Interactome
- Gene Pathway
- Calcium signaling pathway
- Epithelial cell signaling in Helicobacter pylori infection
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Glioma
- Inositol phosphate metabolism
- Leukocyte transendothelial migration
- Metabolic pathways
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Non-small cell lung cancer
- Pathways in cancer
- Phosphatidylinositol signaling system
- T cell receptor signaling pathway
- VEGF signaling pathway
- Vibrio cholerae infection