FITC标记的肿瘤抑制蛋白18抗体
产品名称： FITC标记的肿瘤抑制蛋白18抗体
英文名称： Anti-ST18/FITC
产品编号： HZ-12188R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ST18/FITC Conjugated antibody
FITC标记的肿瘤抑制蛋白18抗体
| 英文名称 | Anti-ST18/FITC |
| 中文名称 | FITC标记的肿瘤抑制蛋白18抗体 |
| 别 名 | KIAA0535; St18; ST18_HUMAN; suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein); Suppression of tumorigenicity 18 protein; Suppression of tumorigenicity protein 18; Zinc finger protein 387; Znf387. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 干细胞 锌指蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 115kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ST18/Znf387 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: ST18 is a 1,047 amino acid nuclear protein that is expressed at low levels in heart, liver, kidney, skeletal muscle, pancreas, testis, ovary and prostate. Containing six C2HC-type zinc fingers and an SMC domain, ST18 is a repressor protein that binds to DNA sequences containing a specific bipartite element. ST18 is considered a transcription factor that represses basal transcription activity from target promoters and Inhibits colony formation in cultured breast cancer cells. ST18 is encoded by a gene located on human chromosome 8, which consists of nearly 146 million base pairs, encodes over 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8. Function: Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity). Inhibits colony formation in cultured breast cancer cells. Subcellular Location: Nucleus. Tissue Specificity: Detected at low levels in heart, liver, kidney, skeletal muscle, pancreas, testis, ovary and prostate. Detected at even lower levels in mammary epithelial cells and breast cancer cells. Similarity: Contains 6 C2HC-type zinc fingers. Database links: Entrez Gene: 9705 Human Entrez Gene: 240690 Mouse Entrez Gene: 266680 Rat SwissProt: O60284 Human SwissProt: Q80TY4 Mouse SwissProt: Q9QX27 Rat Unigene: 655499 Human Unigene: 234612 Mouse Unigene: 91311 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
ST18是一种1047氨基酸核蛋白，在心脏、肝脏、肾脏、骨骼肌、胰腺、睾丸、卵巢和前列腺中低水平表达。ST18包含六个C2HC型锌指和一个SMC结构域，是一种与含有特定二分体元素的DNA序列结合的抑制蛋白。ST18被认为是一种转录因子，它抑制靶启动子的基本转录活性，并抑制培养的乳腺癌细胞的集落形成。ST18是由位于人类8号染色体上的基因编码的，该基因由近1.46亿个碱基对组成，编码800多个基因，与各种疾病和恶性肿瘤有关。精神分裂症、双相情感障碍、8三体、Pfeiffer综合征、先天性甲状腺功能减退、Waardenburg综合征和一些白血病和淋巴瘤被认为是由于映射到8号染色体的特定基因的缺陷而发生的。