FITC标记的干扰素-gamma受体2/干扰素-gamma受体β/IFN-γRβ抗体
产品名称： FITC标记的干扰素-gamma受体2/干扰素-gamma受体β/IFN-γRβ抗体
英文名称： Anti-IFNGR2/FITC
产品编号： HZ-2710R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-IFNGR2/FITC Conjugated antibody
FITC标记的干扰素-gamma受体2/干扰素-gamma受体β/IFN-γRβ抗体
| 英文名称 | Anti-IFNGR2/FITC |
| 中文名称 | FITC标记的干扰素-gamma受体2/干扰素-gamma受体β/IFN-γRβ抗体 |
| 别 名 | IFNGR2; IFN gamma Receptor beta; AF 1; AF1; IFGR 2; IFGR2; IFNGR 2; IFNGT 1; IFNGT1; Interferon gamma receptor 2; Interferon gamma receptor accessory factor 1; Interferon gamma receptor beta chain; Interferon gamma receptor chain 2; Interferon gamma transducer 1; INGR2_HUMAN; gamma receptor 2; IFN-gamma receptor 2; IFN-gamma-R2; Interferon gamma receptor accessory factor 1; AF 1; AF-1; AF1; Interferon gamma transducer 1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 36kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IFNGR2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: IFN gamma receptor beta is part of the receptor for interferon gamma. This class II cytokine receptor pairs with CDw119 to form the IFN gamma receptor and is an integral part of the IFN gamma signal transduction pathway. CDw119 serves as the IFN gamma binding chain and associates with the IFN gamma beta chain which is required for receptor signaling. The extracellular portion of both the IFN gamma receptor alpha and beta chains must be species matched. The IFN gamma receptor beta chain is expressed on T and B cells, NK cells, monocytes/ macrophages, and fibroblasts. Binding of IFN gamma induces receptor dimerization, internalization, Jak1 and Jak2 protein kinase activation and, ultimately, STAT1 activation. It is also likely to interact with GAF. IFN gamma initiates and regulates a variety of immune responses and is required for signal transduction. Contains 2 fibronectin type III domains. Defects in IFN gamma Receptor beta are a cause of mendelian susceptibility to mycobacterial disease (MSMD), a rare condition that confers predisposition to illness caused by several mycobacteria strains. Function: Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2. Subcellular Location: Membrane; Single-pass type I membrane protein. DISEASE: Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. Similarity: Belongs to the type II cytokine receptor family. Contains 2 fibronectin type-III domains. Database links: Entrez Gene: 3460 Human Entrez Gene: 15980 Mouse Entrez Gene: 360697 Rat Omim: 147569 Human SwissProt: P38484 Human Unigene: 634632 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
IFN-γ受体β是干扰素-γ受体的一部分。这类II类细胞因子受体对与CDW119形成IFN-γ受体，是IFN-γ信号转导通路的组成部分。CDW119作为IFN-γ结合链，与IFN-γ-β链相关，这是受体信号所必需的。IFN-γ受体α和β链的胞外部分必须是物种匹配的。IFN-γ受体β链在T细胞和B细胞、NK细胞、单核细胞/巨噬细胞和成纤维细胞上表达。IFN-γ的结合诱导受体二聚化，内化，JAK1和JAK2蛋白激酶激活，并最终STAT1激活。它也可能与GAF相互作用。IFN-γ启动和调节多种免疫应答，是信号转导所必需的。包含2型纤连蛋白Ⅲ型结构域。IFN-γ受体β的缺陷是分枝杆菌病（MMSD）孟德尔易感性的一个原因，这是一种罕见的疾病，它导致了由几种分枝杆菌菌株引起的疾病的易感性。