STAT4 Pre-design Chimera RNAi
产品名称： STAT4 Pre-design Chimera RNAi
英文名称： STAT4 Pre-design Chimera RNAi
产品编号： H00006775-R01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Homo sapiens signal transducer and activator of transcription 4 (STAT4), mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_003151
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 6775
- Gene Name:
- STAT4
- Gene Alias:
- SLEB11
- Gene Description:
- signal transducer and activator of transcription 4
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. [provided by RefSeq
- Other Designations:
- OTTHUMP00000163553
- Gene Pathway
- Related Disease
- Antiphospholipid Syndrome
- Arthritis
- Arthritis, Juvenile Rheumatoid
- Arthritis, Rheumatoid
- Asthma
- Asthma
- Atherosclerosis
- Autoimmune Diseases
- Behcet Syndrome
- Birth Weight
- Brain Ischemia
- Bronchiolitis, Viral
- Cardiovascular Diseases
- Colitis, Ulcerative
- Crohn Disease
- Crohn's disease
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Disease Progression