CHRNB2 Pre-design Chimera RNAi
产品名称： CHRNB2 Pre-design Chimera RNAi
英文名称： CHRNB2 Pre-design Chimera RNAi
产品编号： H00001141-R01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- 邮编 : 11493
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- Specification
- Product Description:
- Homo sapiens cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) (CHRNB2), mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_000748
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 1141
- Gene Name:
- CHRNB2
- Gene Alias:
- EFNL3,nAChRB2
- Gene Description:
- cholinergic receptor, nicotinic, beta 2 (neuronal)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy. [provided by RefSeq
- Other Designations:
- OTTHUMP00000035374,cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal),neuronal nicotinic acetylcholine receptor beta 2
- Related Disease
- Alcoholism
- Alcohol-Related Disorders
- Alzheimer Disease
- Alzheimer disease
- Amphetamine-Related Disorders
- Bipolar Disorder
- Cognition
- Disease Models, Animal
- Epilepsy
- Epilepsy, Frontal Lobe
- Epilepsy, Generalized
- Genetic Predisposition to Disease
- Genetics, Behavioral
- Mental Disorders
- Narcolepsy
- Obesity
- Ovarian Failure, Premature
- Polycystic Ovary Syndrome
- Psychiatric Status Rating Scales