FITC标记的血栓素B2(一种新发现的抑癌基因)抗体
产品名称： FITC标记的血栓素B2(一种新发现的抑癌基因)抗体
英文名称： Anti-TBX2/FITC
产品编号： HZ-0507R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-TBX2/FITC Conjugated antibody
FITC标记的血栓素B2(一种新发现的抑癌基因)抗体
| 英文名称 | Anti-TBX2/FITC |
| 中文名称 | FITC标记的血栓素B2(一种新发现的抑癌基因)抗体 |
| 别 名 | T-box2; T-box Protein 2; T-box transcription factor TBX2; T-box protein 2; FLJ10169; HGNC: 11597; T box 2; T box transcription factor TBX2; TBX2_HUMAN; TBX2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 染色质和核信号 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 74kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TBX2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. Function: Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. Subunit: Interacts with PML (isoform-PML-2, isoform PML-3 and isoform PML-4). Subcellular Location: Nucleus (Potential). Tissue Specificity: Expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary. Similarity: Contains 1 T-box DNA-binding domain. Database links: Entrez Gene: 6909 Human Entrez Gene: 21385 Mouse Omim: 600747 Human SwissProt: Q13207 Human SwissProt: Q60707 Mouse Unigene: 531085 Human Unigene: 287052 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因是一个系统发育保守的基因家族成员，共享一个共同的DNA结合结构域，即T盒。T-box基因编码参与发育过程调控的转录因子。该基因产物是小鼠TBX2的同源基因，与果蝇OMB蛋白具有较强的序列相似性。表达研究表明，该基因可能作为永生化剂在肿瘤发生中具有潜在的作用。该基因已注意到由于多聚腺苷酸化导致的转录异质性。