MAP2K4 (phospho S80) polyclonal antibody
产品名称： MAP2K4 (phospho S80) polyclonal antibody
英文名称： MAP2K4 (phospho S80) polyclonal antibody
产品编号： PAB0511
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of MAP2K4.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S80 of human MAP2K4.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000 Dot Blotting (1:100-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Tobacco smoke control of mucin production in lung cells requires oxygen radicals AP-1 and JNK.
Gensch E, Gallup M, Sucher A, Li D, Gebremichael A, Lemjabbar H, Mengistab A, Dasari V, Hotchkiss J, Harkema J, Basbaum C.J Biol Chem. 2004 Sep 10;279(37):39085-93. Epub 2004 Jul 15.
- 2.
- Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC delta signal transduction.
Woo JH, Lim JH, Kim YH, Suh SI, Min DS, Chang JS, Lee YH, Park JW, Kwon TK.Oncogene. 2004 Mar 11;23(10):1845-53.
- 3.
- Apoptosis signaling triggered by the marine alkaloid ascididemin is routed via caspase-2 and JNK to mitochondria.
Dirsch VM, Kirschke SO, Estermeier M, Steffan B, Vollmar AM.Oncogene. 2004 Feb 26;23(8):1586-93.
- Applications
- Dot Blot (Peptide)
- Dot blot analysis of MAP2K4 (phospho S80) polyclonal antibody (Cat # PAB0511) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentration was 0.5 ug/mL. P-Pab : phospho-antibody; P-Peptide : phospho-peptide; NP-Peptide : non-phospho-peptide.
- Entrez GeneID:
- 6416
- Protein Accession#:
- NP_003001;P45985
- Gene Name:
- MAP2K4
- Gene Alias:
- JNKK,JNKK1,MAPKK4,MEK4,MKK4,PRKMK4,SEK1,SERK1
- Gene Description:
- mitogen-activated protein kinase kinase 4
- Omim ID:
- 601335
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. [provided by RefSeq
- Other Designations:
- JNK activating kinase 1,JNK-activated kinase 1,MAP kinase kinase 4,MAPK/ERK kinase 4,SAPK/ERK kinase 1,c-Jun N-terminal kinase kinase 1,dual specificity mitogen-activated protein kinase kinase 4