IFI35,干扰素诱导35蛋白抗体

产品编号HZ-9704R
英文名称IFI35
中文名称干扰素诱导35蛋白抗体
别 名IFI 35; Ifi-35; IFI35; IFP 35; IFP35; IN35; IN35_HUMAN; Interferon induced 35 kDa protein; Interferon-induced 35 kDa protein.
说 明 书0.1ml 0.2ml
研究领域细胞生物 细胞凋亡 细胞周期蛋白 细胞分化
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow,
IFI35,干扰素诱导35蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-200 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量31kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human IFI35
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
IFI35,干扰素诱导35蛋白抗体PubMedPubMed
产品介绍background:
The Interferon family of proteins are able to alter the expression of a variety of target genes, thereby controlling various events within the cell. IFI-35 (Interferon-induced 35 kDa protein), also known as IFP35, is a 286 amino acid interferon-induced protein. Localized to the nucleus and expressed in macrophages, fibroblasts and epithelial cells, IFI-35 is a leucine zipper protein that can form homodimers, but, unlike most leucine zipper proteins, cannot bind DNA. Upon induction by IFN-? IFI-35 associates with Nmi (N-Myc-interacting protein), resulting in the formation of a high molecular weight complex that is thought to play a role in IFN-?signaling and cellular responses. Once complexed with Nmi, IFI-35 is unable to be degraded by the proteasome, suggesting that IFI-35 is protected from degradation only when needed by IFN-? Two isoforms of IFI-35 exist due to alternative splicing events.

Function:
Not yet known.

Subunit:
Homodimer. Also interacts with B-ATF.

Subcellular Location:
Nucleus. Nuclear following IFN treatment.

Tissue Specificity:
In a wide range of cell types, including fibroblasts, macrophages, and epithelial cells.

IFI35,干扰素诱导35蛋白抗体Similarity:
Belongs to the NMI family.

Gene ID:
3430

Database links:
Entrez Gene: 3430 Human
Omim: 600735 Human
SwissProt: P80217 Human
Unigene: 632258 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.