FITC标记的上皮粘连调控蛋白ESRP2抗体
产品名称： FITC标记的上皮粘连调控蛋白ESRP2抗体
英文名称： Anti-ESRP2/FITC
产品编号： HZ-13108R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ESRP2/FITC Conjugated antibody
| FITC标记的上皮粘连调控蛋白ESRP2抗体 |
| 英文名称 | Anti-ESRP2/FITC |
| 中文名称 | FITC标记的上皮粘连调控蛋白ESRP2抗体 |
| 别 名 | Epithelial splicing regulatory protein 2; ESRP 2; ESRP2; ESRP2_HUMAN; FLJ21918; FLJ22248; RBM35B; RNA binding motif protein 35A; RNA binding motif protein 35B; RNA binding protein 35B; RNA-binding motif protein 35B; RNA-binding protein 35B. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 细胞粘附分子 细胞类型标志物 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 78kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ESRP2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. Function: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. Subcellular Location: Nucleus. Tissue Specificity: Epithelial cell-specific. Similarity: Belongs to the ESRP family. Contains 3 RRM (RNA recognition motif) domains. Database links: UniProtKB/Swiss-Prot: Q9H6T0.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
mRNA剪接因子，调节上皮细胞特异性亚型的形成。特异性调节FGFR2 IIIb的表达，FGFR2的上皮细胞特异性亚型。还调节CD44、CTNND1、ENAH、3个转录本的剪接，这些转录本在上皮-间充质转变(EMT)期间经历剪接改变。通过直接结合mRNA的特异序列来实现。结合在ISE/ISS-3中的Gu富含序列基序，存在于FGFR2 mRNA中的顺式元件调控区。