重组人中性粒细胞明胶酶相关脂质运载蛋白(NGAL)(LCN2)

中文名称：重组人中性粒细胞明胶酶相关脂质运载蛋白(NGAL)(LCN2)
英文名称：Recombinant Human Neutrophil gelatinase-associated lipocalin
产品规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Gln21-Gly198在C端含有His标签。

LCN2质量控制：＞95%(还原性SDS-PAGE)

LCN2制剂：液体

LCN2保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于LCN2：
LCN2 is iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. LCN2 binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. LCN2 is involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. LCN2 is involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. 

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