FITC标记的RAS相关抑细胞生长蛋白1抗体
产品名称： FITC标记的RAS相关抑细胞生长蛋白1抗体
英文名称： Anti-DIRAS1/FITC
产品编号： HZ-6163R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-DIRAS1/FITC Conjugated antibody
FITC标记的RAS相关抑细胞生长蛋白1抗体
| 英文名称 | Anti-DIRAS1/FITC |
| 中文名称 | FITC标记的RAS相关抑细胞生长蛋白1抗体 |
| 别 名 | Di Ras1; DIRAS family GTP binding RAS like 1; Distinct subgroup of the Ras family member 1; GBTS1; GTP binding protein Di Ras1; Ras related inhibitor of cell growth; RIG; Rig protein; Small GTP binding tumor suppressor 1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 转录调节因子 G蛋白偶联受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 22kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DIRAS1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The three human RAS genes encode highly related 188 to 189 amino acid proteins, designated H-Ras, N-Ras and K-Ras4A and K-Ras4B (the two K-Ras proteins arise from alternative gene splicing). Ras proteins function as binary molecular switches that control intracellular signaling networks. Ras-regulated signal pathways control such processes as actin cytoskeletal integrity, proliferation, differentiation, cell adhesion, apoptosis, and cell migration. Ras and ras-related proteins are often deregulated in cancers, leading to increased invasion and metastasis, and decreased apoptosis. DIRAS1 displays low GTPase activity and exists predominantly in the GTP-bound form. It is highly expressed in heart and brain. Function: Displays low GTPase activity and exist predominantly in the GTP-bound form. Subcellular Location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Tissue Specificity: Highly expressed in heart and brain. Similarity: Belongs to the small GTPase superfamily. Di-Ras family. Database links: UniProtKB/Swiss-Prot: O95057.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
三个人类ras基因编码高度相关的188到189个氨基酸的蛋白质，指定H-ras、N-ras和K-ras4a和K-ras4b（两个K-ras蛋白来自选择性的基因剪接）。Ras蛋白作为控制细胞内信号网络的二元分子开关发挥作用。RAS调节的信号通路控制肌动蛋白细胞骨架完整性、增殖、分化、细胞粘附、凋亡和细胞迁移等过程。Ras和Ras相关蛋白在癌症中常被解除管制，导致侵袭和转移增加，细胞凋亡减少。DRAS1显示低GTP酶活性，主要存在于GTP结合形式。它在心脏和脑中高度表达。