FITC标记的PDZ和LIM结构域结合蛋白7抗体
产品名称： FITC标记的PDZ和LIM结构域结合蛋白7抗体
英文名称： Anti-PDLIM7/FITC
产品编号： HZ-12603R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PDLIM7/FITC Conjugated antibody
FITC标记的PDZ和LIM结构域结合蛋白7抗体
| 英文名称 | Anti-PDLIM7/FITC |
| 中文名称 | FITC标记的PDZ和LIM结构域结合蛋白7抗体 |
| 别 名 | 1110003B01Rik; Enigma; LIM domain protein; LIM domain protein enigma; LIM mineralization protein 1; Lim mineralization protein 3; LIM mineralization protein; LMP 1; LMP; LMP1; LMP3; PDLI7_HUMAN; PDLIM 7; Pdlim7; PDZ and LIM doamin protein 7; PDZ and LIM domain 7; PDZ and LIM domain protein 7; Protein enigma. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 转录调节因子 结合蛋白 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit, Zebrafish, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 50kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PDLIM7 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008] Function: May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway. Subcellular Location: Cytoplasm. Cytoplasm > cytoskeleton. Colocalizes with RET to the cell periphery and in some cytoskeletal components. Colocalizes with TPM2 near the Z line in muscle. Co-localizes with TBX4 and TBX5 to actin filaments. Tissue Specificity: Isoform 1 and isoform 2 are expressed ubiquitously, however, isoform 2 predominates in skeletal muscle, isoform 1 is more abundant in lung, spleen, leukocytes and fetal liver. Similarity: Contains 3 LIM zinc-binding domains. Contains 1 PDZ (DHR) domain. Database links: Entrez Gene: 533851 Cow Entrez Gene: 611246 Dog Entrez Gene: 100712754 Guinea pig Entrez Gene: 100058356 Horse Entrez Gene: 9260 Human Entrez Gene: 67399 Mouse Entrez Gene: 286908 Rat Entrez Gene: 393813 Zebrafish Omim: 605903 Human SwissProt: Q3SX40 Cow SwissProt: Q9NR12 Human SwissProt: Q3TJD7 Mouse SwissProt: Q9Z1Z9 Rat SwissProt: Q6P7E4 Zebrafish Unigene: 533040 Human Unigene: 275648 Mouse Unigene: 7274 Rat Unigene: 118064 Zebrafish Unigene: 121170 Zebrafish Unigene: 85085 Zebrafish Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
由该基因编码的蛋白质是由保守PDZ和LIM结构域组成的蛋白质家族的代表。LIM结构域在蛋白质-蛋白质识别中具有广泛的功能，包括基因转录和发育以及细胞骨架相互作用。该蛋白质的LIM结构域结合蛋白激酶，而PDZ结构域与肌动蛋白丝结合。基因产物参与肌动蛋白丝相关复合物的组装，该复合物对于ret/ptc2有丝分裂信号传导是必不可少的。生物功能很可能是适配器的功能，PDZ结构域将LIM结合蛋白定位于骨骼肌和非肌肉组织的肌动蛋白丝。该基因的选择性剪接导致多个转录变体。[ RefSeq，JUL 2008 ]