FITC标记的染色质组装因子1P55抗体
产品名称： FITC标记的染色质组装因子1P55抗体
英文名称： Anti-CAF1p55/VPRBP/FITC
产品编号： HZ-9393R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 IF=1:50-200
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Rabbit Anti-CAF1p55/VPRBP/FITC Conjugated antibody
FITC标记的染色质组装因子1P55抗体
| 产品编号 | bs-9393R-FITC |
| 英文名称 | Anti-CAF1p55/VPRBP/FITC |
| 中文名称 | FITC标记的染色质组装因子1P55抗体 |
| 别 名 | Caf 1; CAF-1; CAF-1 P55 subunit; CAF1 p55 subunit; p55/DCAF1; CAF1A; CAF1P55; chaf1b; Chromatin assembly factor 1 p55 subunit; Chromatin assembly factor 1 p60 subunit; chromatin assembly factor 1 subunit; Chromatin assembly factor I; dCAF-1; dCAF1; Human chromatin assembly factor-I p55 subunit; Nucleosome remodeling factor 55 kDa subunit; NURF 55; NURF-55; p55; Probable histone binding protein Caf1; VPRBP_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Rabbit, |
| 产品应用 | Flow-Cyt=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 169kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human p55/DCAF1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: P55 is an extensively palmitoylated erythrocyte membrane protein, and a member of the MAGUK family. P55 also resists salt extraction, resulting in a high affinity for the plasma membrane. P55 contains a PDZ/DHR domain, a conserved SH-3 domain that appears to suppress tyrosine kinase activity of various oncoproteins, a 39-amino acid motif that binds to cytoskeletal protein 4.1R, and a guanylate kinase-like domain. Interaction with glycophorin C (GPC) and 4.1R suggests that p55 may play a role in the dynamic regulation in the erythrocyte membrane. In addition, p55 gene expression in vivo may be associated with a CpG island. P55 is constitutively expressed in K562 erythroleukemia cells during erythropoiesis and undergoes a 2-fold amplification after induction. Function: Component of the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex, VprBP/DCAF1 may function as the substrate recognition module within this complex. For example, VprBP/DCAF1 targets NF2 to the E3 ubiquitin-ligase complex for ubiquitination and subsequent proteasome-dependent degradation. In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1 function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1 function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage. Associated with chromatin in a DDB1-independent and cell cycle-dependent manner, VprBP/DCAF1 is recruited to chromatin as DNA is being replicated and is released from chromatin before mitosis. Subunit: Component of the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex that could interact with HIV-1 virus Vpr protein and HIV-2 virus Vpx protein. Interacts directly with DDB1. Also forms a ternary complex with DDA1 and DDB1. Interacts with NF2 (via FERM domain). Component of EDD/UBR5-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and VPRBP proteins (EDVP complex). Interacts directly with DYRK2. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Ubiquitously expressed. Similarity: Belongs to the VPRBP/DCAF1 family. Contains 1 LisH domain. Contains 5 WD repeats. Database links: Entrez Gene: 9730 Human Entrez Gene: 321006 Mouse Entrez Gene: 315987 Rat SwissProt: Q9Y4B6 Human SwissProt: Q80TR8 Mouse Unigene: 716623 Human Unigene: 440089 Mouse Unigene: 32961 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
P55是一种广泛的棕榈酰化红细胞膜蛋白，是MAGUK家族的成员。P55还抵抗盐提取，导致对质膜的高亲和性。P55包含一个PDZ/DHR结构域，一个保守的SH-3结构域，其似乎抑制各种癌蛋白的酪氨酸激酶活性，结合细胞骨架蛋白4.1R的39个氨基酸基序和鸟苷酸激酶样结构域。与糖蛋白C（GPC）和4.1R的相互作用提示P55可能在红细胞膜的动态调节中起作用。此外，p55基因在体内的表达可能与CpG岛有关。P55在红细胞生成过程中在K562红白血病细胞中表达，并在诱导后经历2倍的扩增。