Uniprot ID:P26664
Species Reactivity:Hepatitis C virus genotype 1a
Antibody type:Polyclonal Antibody
Aliases:Capsid protein C,p21,gp32,gp35,NS1,gp68,gp70,p23,Hepacivirin,NS3P,p70,NS4A,NS4B,p27,NS5A,p56,NS5B,p68Raised in:Rabbit
Background\Function :Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways and apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. Thought to play a role in virus-mediated cell transformation leading to hepatocellular carcinomas. Interacts with, and activates STAT3 leading to cellular transformation. May repress the promoter of p53, and sequester CREB3 and SP110 isoform 3/Sp110b in the cytoplasm. Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation. Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, and activates AP-1. Could mediate apoptotic pathways through association with TNF-type receptors TNFRSF1A and LTBR, although its effect on death receptor-induced apoptosis remains controversial. Enhances TRAIL mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury. Seric core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation. May transactivate human MYC, Rous sarcoma virus LTR, and SV40 promoters. May suppress the human FOS and HIV-1 LTR activity. Alters lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage. Core protein induces up-regulation of FAS promoter activity, and thereby probably contributes to the increased triglyceride accumulation in hepatocytes (steatosis) (By similarity).
Stroage Buffer:Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purity:Caprylic Acid Ammonium Sulfate Precipitation purified
武汉华美生物工程有限公司专营基因、蛋白、抗体、ELISA试剂盒、诊断试剂原料、药物残留、食品安全小分子及其他小分子等高质量生物产品，我们的产品涉及血管生成、细胞凋亡/自噬、合成/代谢、血液凝固、细胞粘附、细胞周期、补体、发育蛋白、DNA损伤/DNA修复、细胞因子、药物残留与食品安全、受精作用、生长因子、神经生物学、氧化应激、信息受体、转录/转录调控、运输、泛素、信号传导通路、自身免疫等多个研究领域，包括涵盖37个种属的多达万种的ELISA试剂盒。详细信息请登录：www.cusabio.cn/