The ZR Genomic DNA Kit is based on a simple one buffer procedure for rapid genomic DNA isolation. The kit is optimized to produce high quality DNA without RNA contamination. The ZR Genomic DNA Kit is designed for whole fresh blood, whole stored blood, frozen blood, buffy coat, bone marrow tissue cultured cells, solid tissue, buccal cells, cell culture, and liquid samples. The uniquely formulated Genomic Lysis Buffer directly lyses the cells and releases the DNA. The procedure then relies upon the rapid adsorption of the released DNA onto the surface of the Zymobeads™ in the buffer at the same time. The DNA/Zymobead complex is separated by brief centrifugation and wash steps are performed to remove contaminants. DNA is eluted in water. The yield of DNA is quantitative, reproducible and the DNA is of good purity for direct molecular biology applications such as PCR, restriction enzyme digest, cloning, DNA sequencing, Southern Blot analysis, etc.