FITC标记的白细胞介素18结合蛋白抗体
产品名称： FITC标记的白细胞介素18结合蛋白抗体
英文名称： Anti-IL18BP/FITC
产品编号： HZ-4040R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-IL18BP/FITC Conjugated antibody
FITC标记的白细胞介素18结合蛋白抗体
| 英文名称 | Anti-IL18BP/FITC |
| 中文名称 | FITC标记的白细胞介素18结合蛋白抗体 |
| 别 名 | IL18 BP; IL18 BPa; IL18BP; IL18BPa; Interleukin 18 binding protein; Tadekinig alfa; I18BP_HUMAN; IL-18BP; Interleukin-18-binding protein |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 转录调节因子 结合蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 18kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IL18BP |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: IL18 binding protein binds to IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18 induced IFN gamma production. It is constitutively expressed and secreted in mononuclear cells and can be enhanced by IFN gamma. An elevated level of this protein is detected in the intestinal tissues of patients with Crohn disease. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. Function: Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. Subcellular Location: Secreted. Tissue Specificity: Strongly expressed in heart, lung, placenta and spleen. Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Database links: Entrez Gene: 10068 Human Entrez Gene: 84388 Rat Omim: 604113 Human SwissProt: O95998 Human Unigene: 591967 Human Unigene: 20083 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
IL18结合蛋白与IL18结合，阻止IL18与其受体的结合，从而抑制IL18诱导的IFN-γ产生。它是由单核细胞组成表达和分泌的，可以通过IFN-γ增强。在克罗恩病患者的肠道组织中检测到这种蛋白的升高水平。报道了四种编码不同亚型的剪接转录变体。