GCH1 (Human) Recombinant Protein (P01)
产品名称： GCH1 (Human) Recombinant Protein (P01)
英文名称： GCH1 (Human) Recombinant Protein (P01)
产品编号： H00002643-P01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Human GCH1 full-length ORF ( AAH25415.1, 1 a.a. - 250 a.a.) recombinant protein with GST-tag at N-terminal.
- Sequence:
- MEKGPVRAPAEKPRGARCSNGFPERDPPRPGPSRPAEKPPRPEAKSAQPADGWKGERPRSEEDNELNLPNLAAAYSSILSSLGENPQRQGLLKTPWRAASAMQFFTKGYQETISDVLNDAIFDEDHDEMVIVKDIDMFSMCEHHLVPFVGKVHIGYLPNKQVLGLSKLARIVEIYSRRLQVQERLTKQIAVAITEALRPAGVGVVVEATHMCMVMRGVQKMNSKTVTSTMLGVFREDPKTREEFLTLIRS
- Theoretical MW (kDa):
- 53.24
- Preparation Method:
- in vitro wheat germ expression system
- Purification:
- Glutathione Sepharose 4 Fast Flow
- Storage Buffer:
- 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
- Storage Instruction:
- Store at -80°C. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- 12.5% SDS-PAGE Stained with Coomassie Blue.
- Note:
- Best use within three months from the date of receipt of this protein.
- MSDS:
Download
- Publication Reference
- 1.
- Regulation of Tetrahydrobiopterin Biosynthesis by Shear Stress.
Widder JD, Chen W, Li L, Dikalov S, Thony B, Hatakeyama K, Harrison DG.Circ Res. 2007 Oct 12;101(8):830-8. Epub 2007 Aug 17.
- Application Image
- Enzyme-linked Immunoabsorbent Assay
- Western Blot (Recombinant protein)
- Antibody Production
- Protein Array
- Entrez GeneID:
- 2643
- GeneBank Accession#:
- BC025415
- Protein Accession#:
- AAH25415.1
- Gene Name:
- GCH1
- Gene Alias:
- DYT14,DYT5,GCH,GTP-CH-1,GTPCH1
- Gene Description:
- GTP cyclohydrolase 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme. [provided by RefSeq
- Other Designations:
- guanosine 5'-triphosphate cyclohydrolase I
- Gene Pathway
- Related Disease
- Acute Disease
- Autistic Disorder
- Cardiovascular Diseases
- Cerebrovascular Disorders
- Chromosome Aberrations
- Chromosome Deletion
- Chronic Disease
- Coronary Artery Disease
- Coronary Disease
- Diabetes Mellitus, Type 2
- Diabetic Angiopathies
- Dystonia
- Dystonic Disorders
- Edema
- Genetic Predisposition to Disease
- Hypertension
- Labor Pain
- Low Back Pain
- Mental Retardation