Catalog Number:AF-210-10
Description:
IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNF-α. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 is active on murine cells, but murine IL-10 is inactive on human cells. Recombinant Murine IL-10 is an 18.7 kDa protein of 161 amino acid residues.
Manufactured using all Animal-Free reagents.
Source:E.coli
Synonyms:Interleukin-10, B-TCGF, CSIF, TGIF
AA Sequence:MSRGQYSRED NNCTHFPVGQ SHMLLELRTA FSQVKTFFQT KDQLDNILLT DSLMQDFKGY LGCQALSEMI QFYLVEVMPQ AEKHGPEIKE HLNSLGQKLK TLRMRLRRCH RFLPCENKSK AVEQVKSDFN KLEDQGVYKA MNEFDIFINC IEAYMMIKMK S
Purity:≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:Determined by the dose-dependent co-stimulation (with murine IL-4) of MC/9 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
Research Interest
 AIDS / HIV  Immune System Inflammation  Neurobiology Stem Cells & Differentiation  Allergy Transplantation  Cancer
PubMed
SDS
Product Line
Country Of Origin: USA
Not for human use.