FITC标记的脑组织表达X连锁蛋白1抗体
产品名称： FITC标记的脑组织表达X连锁蛋白1抗体
英文名称： Anti-Bex1/FITC
产品编号： HZ-5993R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Bex1/FITC Conjugated antibody
FITC标记的脑组织表达X连锁蛋白1抗体
| 英文名称 | Anti-Bex1/FITC |
| 中文名称 | FITC标记的脑组织表达X连锁蛋白1抗体 |
| 别 名 | BEX2; Brain expressed X linked 1; HBEX2; Protein BEX1; BEX1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 神经生物学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 15kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HBEX2/Bex1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The brain-expressed X-linked (Bex) family of proteins is expressed in the central nervous system, with highest levels detected in cerebellum, temporal lobe and pituitary tissues. Bex1 plays an important role in neuronal differentiation in response to nerve growth factor (NGF), as well as in cell cycle progression. Bex1 is a highly ubiquitinated protein and acts as a link between the cell cycle and neurotrophic factor signaling. Bex2 interacts with LMO2, thereby regulating the transcriptional activity of a DNA-binding complex. Bex1 and Bex 2 are widely expressed outside of the central nervous system with high expression in the liver. Bex1 and Bex2 shuttle between the cytoplasm and the nucleus. Though the role of Bex1 is largely unknown, it may function by coordinating internal cellular states with the ability of cells to respond to external signals. Function: ] Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity). Subunit: Interacts with neurotrophin receptor p75NTR/NGFR. Interacts with OMP (By similarity). Subcellular Location: Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus (By similarity). Tissue Specificity: Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Expressed in lung, skeletal muscle, peripheral blood leukocyte, stomach, lymph node, trachea and bone marrow. Highly expressed in acute myeloid leukemia. Post-translational modifications: Phosphorylated. Phosphorylation of Ser-102 protects it from the proteasome (By similarity). Ubiquitinated. Degraded by the proteasome (By similarity). Similarity: Belongs to the BEX family. Database links: UniProtKB/Swiss-Prot: Q9HBH7.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
表达X连锁（Bex）蛋白的脑在中枢神经系统中表达，在小脑、颞叶和垂体组织中检测到最高水平。BEX1在神经分化中起重要作用，对神经生长因子（NGF）和细胞周期进程也起重要作用。BEX1是高度泛素化的蛋白，是细胞周期和神经营养因子信号传导的纽带。BEX2与LMO2相互作用，从而调节DNA结合复合物的转录活性。BEX1和BEX 2广泛表达于中枢神经系统外，在肝脏中高表达。BEX1和BEX2穿梭于细胞质和细胞核之间。虽然BEX1的作用在很大程度上是未知的，但它可以通过协调细胞内部状态与细胞对外部信号的反应能力来发挥作用。