FITC标记的FATE1蛋白抗体
产品名称： FITC标记的FATE1蛋白抗体
英文名称： Anti-FATE1/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-FATE1/FITC Conjugated antibody
FITC标记的FATE1蛋白抗体
| 英文名称 | Anti-FATE1/FITC |
| 中文名称 | FITC标记的FATE1蛋白抗体 |
| 别 名 | Cancer/testis antigen 43; CT43; FATE; FATE1; FATE1_HUMAN; fetal and adult testis expressed 1; fetal and adult testis expressed transcript protein; Fetal and adult testis-expressed transcript protein; Protein BJ HCC 2; Tumor antigen BJ-HCC-2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 21kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FATE1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: FATE1 (fetal and adult testis expressed 1), also known as FATE, CT43 (cancer/testis antigen 43) or BJ-HCC-2, is a cancer/testis antigen found in testis and tumor tissues (specifically hepatocarcinoma cells). Its expression is regulated by SF-1 (Steroidogenic Factor 1) and WT1 (Wilms’ tumor protein), two proteins involved in tumorigenesis, suggesting a role for FATE1 in tumor development. FATE1 is exclusively expressed in testis of the 6-11 week old fetus (around the period of gonadal sex differentiation). At 7 weeks, FATE1 is coexpressed with SRY and may play a role in early testicular differentiation. In adults, although predominantly expressed in testis, FATE1 can also be found in heart, kidney, brain, lung and adrenal gland. Mutations in the gene encoding FATE1 may be contributing factors in male infertility. Subcellular Location: Membrane. Tissue Specificity: Testis-specific in fetus (aged from 6 to 11 weeks). In adult, expressed predominantly in testis, with some expression in lung, heart, kidney, adrenal gland and whole brain. Database links: Entrez Gene: 89885 Human Omim: 300450 Human SwissProt: Q969F0 Human Unigene: 301960 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
FATE1(胎儿和睾丸表达1)，也称为FATE、CT43(癌症/睾丸抗原43)或BJ-HCC-2，是在睾丸和肿瘤组织(特别是肝癌细胞)中发现的癌症/睾丸抗原。其表达受SF-1(甾体生成因子1)和WT1(Wilms'肿瘤蛋白)的调节，这两种蛋白参与肿瘤的发生，提示FATE1在肿瘤发生中的作用。FATE1仅在6-11周龄的胎儿睾丸中表达（在性腺分化期）。在7周时，FATE1与SRY共表达，可能在睾丸分化早期起作用。在中，虽然在睾丸中主要表达，FATE1也可在心脏、肾脏、脑、肺和肾上腺中发现。FATE1基因突变可能是男性不育的致病因素。